A Single Mechanism for Global and Selective Response Inhibition under the Influence of Motor Preparation.
Adolescent
Adult
Anticipation, Psychological
/ physiology
Cortical Synchronization
Cues
Electroencephalography
Electromyography
Evoked Potentials, Motor
/ physiology
Female
Functional Laterality
/ physiology
Humans
Male
Movement
/ physiology
Neural Inhibition
/ physiology
Psychomotor Performance
/ physiology
Reaction Time
Young Adult
EEG
EMG
TMS
cognitive control
motor control
response inhibition
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
07 10 2020
07 10 2020
Historique:
received:
12
03
2020
revised:
09
07
2020
accepted:
30
07
2020
pubmed:
16
9
2020
medline:
20
1
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
In our everyday behavior, we frequently cancel one movement while continuing others. Two competing models have been suggested for the cancellation of such specific actions: (1) the abrupt engagement of a unitary global inhibitory mechanism followed by reinitiation of the continuing actions; or (2) a balance between distinct global and selective inhibitory mechanisms. To evaluate these models, we examined behavioral and physiological markers of proactive control, motor preparation, and response inhibition using a combination of behavioral task performance measures, electromyography, electroencephalography, and motor evoked potentials elicited with transcranial magnetic stimulation. Healthy human participants of either sex performed two versions of a stop signal task with cues incorporating proactive control: a unimanual task involving the initiation and inhibition of a single response, and a bimanual task involving the selective stopping of one of two prepared responses. Stopping latencies, motor evoked potentials, and frontal β power (13-20 Hz) did not differ between the unimanual and bimanual tasks. However, evidence for selective proactive control before stopping was manifest in the bimanual condition as changes in corticomotor excitability, μ (9-14 Hz), and β (15-25 Hz) oscillations over sensorimotor cortex. Together, our results favor the recruitment of a single inhibitory stopping mechanism with the net behavioral output depending on the levels of action-specific motor preparation.
Identifiants
pubmed: 32928884
pii: JNEUROSCI.0607-20.2020
doi: 10.1523/JNEUROSCI.0607-20.2020
pmc: PMC7548697
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7921-7935Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR002370
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092079
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
Références
Elife. 2020 Mar 18;9:
pubmed: 32186515
Trends Neurosci. 2017 Apr;40(4):219-236
pubmed: 28341235
J Neurophysiol. 2007 Mar;97(3):2480-9
pubmed: 17251361
Neuropsychologia. 2014 Dec;65:263-78
pubmed: 25149820
Exp Brain Res. 2015 Mar;233(3):679-89
pubmed: 25563496
Cereb Cortex. 2012 Feb;22(2):363-71
pubmed: 21666129
J Neurophysiol. 2013 Aug;110(4):883-90
pubmed: 23699058
J Neurosci. 2009 Oct 7;29(40):12675-85
pubmed: 19812342
PLoS One. 2018 May 16;13(5):e0196855
pubmed: 29768455
Neuroimage. 2020 Apr 15;210:116582
pubmed: 31987997
Front Syst Neurosci. 2014 Nov 03;8:206
pubmed: 25404898
J Neurosci. 2016 Aug 17;36(33):8726-33
pubmed: 27535917
Neuropsychologia. 2010 Jan;48(2):541-8
pubmed: 19879283
Psychol Rev. 2014 Jan;121(1):66-95
pubmed: 24490789
Psychol Sci. 2013 Mar 1;24(3):352-62
pubmed: 23399493
Clin Neurophysiol. 2009 Sep;120(9):1717-23
pubmed: 19683959
J Cogn Neurosci. 2010 Feb;22(2):225-39
pubmed: 19400674
Trends Cogn Sci. 2011 Oct;15(10):453-9
pubmed: 21889391
J Neurosci. 2009 Dec 16;29(50):15870-7
pubmed: 20016103
Neuron. 2017 Jan 18;93(2):259-280
pubmed: 28103476
Cogn Psychol. 2016 May;86:27-61
pubmed: 26859519
Annu Rev Neurosci. 2010;33:269-98
pubmed: 20345247
Perspect Psychol Sci. 2014 Sep;9(5):497-524
pubmed: 25419227
Hum Brain Mapp. 2009 Jun;30(6):1791-800
pubmed: 19308934
Prog Brain Res. 2006;159:211-22
pubmed: 17071233
Clin Neurophysiol. 2006 Feb;117(2):348-68
pubmed: 16356767
Front Neuroeng. 2012 Jun 19;5:9
pubmed: 22723779
J Neurosci. 2018 May 2;38(18):4367-4382
pubmed: 29636393
Brain Topogr. 2017 Jul;30(4):486-501
pubmed: 28456867
J Neurophysiol. 2019 Oct 1;122(4):1357-1366
pubmed: 31339791
Neuroimage. 2020 Aug 5;222:117222
pubmed: 32768628
Behav Res Methods. 2019 Apr;51(2):961-985
pubmed: 29959755
J Neurophysiol. 2018 Mar 1;119(3):877-886
pubmed: 29212923
J Neurophysiol. 2012 Sep;108(5):1492-500
pubmed: 22696543
J Neurophysiol. 2012 Jan;107(1):384-92
pubmed: 22013239
J Neurophysiol. 2016 Aug 1;116(2):859-67
pubmed: 27281744
Brain Lang. 2012 Mar;120(3):412-5
pubmed: 22206872
Biol Psychiatry. 2011 Jun 15;69(12):e55-68
pubmed: 20932513
PLoS One. 2015 Oct 21;10(10):e0140383
pubmed: 26488166
Front Hum Neurosci. 2010 Nov 04;4:186
pubmed: 21119777
Philos Trans R Soc Lond B Biol Sci. 2017 Apr 19;372(1718):
pubmed: 28242727
Eur J Neurosci. 2016 Aug;44(4):2095-103
pubmed: 27306544
J Neurosci Methods. 2015 Jul 30;250:47-63
pubmed: 25791012
Behav Res Methods. 2017 Feb;49(1):267-281
pubmed: 26822670
Cognition. 2015 Sep;142:81-95
pubmed: 26036922
J Exp Psychol Hum Percept Perform. 1997 Oct;23(5):1533-42
pubmed: 9411024
Sci Rep. 2020 May 8;10(1):7749
pubmed: 32385323
J Exp Psychol Gen. 2014 Feb;143(1):455-72
pubmed: 23477668
J Cogn Neurosci. 2011 Sep;23(9):2481-93
pubmed: 20849230
J Neurosci. 2013 Nov 13;33(46):18087-97
pubmed: 24227719
Cortex. 2020 Aug 5;132:334-348
pubmed: 33017748
Curr Biol. 2014 Dec 15;24(24):2940-5
pubmed: 25484293
Neuroimage. 2012 Feb 1;59(3):2860-70
pubmed: 21979383
Elife. 2019 Apr 29;8:
pubmed: 31033438
J Cogn Neurosci. 2019 May;31(5):657-668
pubmed: 30633601
Neuropsychologia. 1971 Mar;9(1):97-113
pubmed: 5146491
Front Hum Neurosci. 2014 Dec 10;8:994
pubmed: 25540615
Psychol Sci. 2008 Nov;19(11):1146-53
pubmed: 19076487
J Neurosci. 2015 Jul 29;35(30):10675-84
pubmed: 26224853
Neuropsychologia. 2019 Jun;129:212-222
pubmed: 31015024
Front Hum Neurosci. 2017 Apr 27;11:204
pubmed: 28496405
J Cogn Neurosci. 2010 Jul;22(7):1479-92
pubmed: 19583473
J Neurosci Methods. 2018 Jan 15;294:34-39
pubmed: 29103999
J Neurosci. 2011 Apr 20;31(16):5965-9
pubmed: 21508221
Front Hum Neurosci. 2014 Feb 18;8:61
pubmed: 24600371
J Neurophysiol. 2015 Jan 15;113(2):455-65
pubmed: 25339712
J Exp Psychol Hum Percept Perform. 1990 Feb;16(1):164-182
pubmed: 2137517
J Neurophysiol. 2014 Dec 1;112(11):2707-17
pubmed: 25185817
J Cogn Neurosci. 2018 Jan;30(1):107-118
pubmed: 28880766
J Neurosci. 2012 Aug 8;32(32):10870-8
pubmed: 22875921
Acta Psychol (Amst). 2003 Feb;112(2):105-42
pubmed: 12521663
Psychol Rev. 2007 Apr;114(2):376-97
pubmed: 17500631
J Neurosci. 2020 Jan 8;40(2):411-423
pubmed: 31748375
Percept Psychophys. 2003 Apr;65(3):420-8
pubmed: 12785072
J Neurosci Methods. 2004 Mar 15;134(1):9-21
pubmed: 15102499