Racial and Ethnic Differences in Sarcoma Incidence Are Independent of Census-Tract Socioeconomic Status.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
06
04
2020
revised:
15
06
2020
accepted:
26
08
2020
pubmed:
16
9
2020
medline:
22
12
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Epidemiologic analyses of sarcoma are limited by the heterogeneity and rarity of the disease. Utilizing population-based surveillance data enabled us to evaluate the contribution of census tract-level socioeconomic status (CT-SES) and race/ethnicity on sarcoma incidence rates. We utilized the Surveillance, Epidemiology, and End Results program to evaluate associations between CT-SES and race/ethnicity on the incidence rates of sarcoma. Incidence rate ratios and 99% confidence intervals were estimated from quasi-Poisson models. All models were stratified by broad age groups (pediatric: <20 years, adult: 20-65 years, older adult: 65+ years) and adjusted for sex, age, and year of diagnosis. Within each age group, we conducted analyses stratified by somatic genome (fusion-positive and fusion-negative sarcomas) and for subtypes with >200 total cases. A We included 55,415 sarcoma cases in 35 sarcoma subtype-age group combinations. Increasing CT-SES was statistically significantly associated with 11 subtype-age group combinations, primarily in the older age group strata (8 subtypes), whereas malignant peripheral nerve sheath tumors in adults were associated with decreasing CT-SES. Nearly every sarcoma subtype-age group combination displayed racial/ethnic disparities in incidence that were independent of CT-SES. We found race/ethnicity to be more frequently associated with sarcoma incidence than CT-SES. Our findings suggest that genetic variation associated with ancestry may play a stronger role than area-level SES-related factors in the etiology of sarcoma. These findings provide direction for future etiologic studies of sarcomas.
Sections du résumé
BACKGROUND
Epidemiologic analyses of sarcoma are limited by the heterogeneity and rarity of the disease. Utilizing population-based surveillance data enabled us to evaluate the contribution of census tract-level socioeconomic status (CT-SES) and race/ethnicity on sarcoma incidence rates.
METHODS
We utilized the Surveillance, Epidemiology, and End Results program to evaluate associations between CT-SES and race/ethnicity on the incidence rates of sarcoma. Incidence rate ratios and 99% confidence intervals were estimated from quasi-Poisson models. All models were stratified by broad age groups (pediatric: <20 years, adult: 20-65 years, older adult: 65+ years) and adjusted for sex, age, and year of diagnosis. Within each age group, we conducted analyses stratified by somatic genome (fusion-positive and fusion-negative sarcomas) and for subtypes with >200 total cases. A
RESULTS
We included 55,415 sarcoma cases in 35 sarcoma subtype-age group combinations. Increasing CT-SES was statistically significantly associated with 11 subtype-age group combinations, primarily in the older age group strata (8 subtypes), whereas malignant peripheral nerve sheath tumors in adults were associated with decreasing CT-SES. Nearly every sarcoma subtype-age group combination displayed racial/ethnic disparities in incidence that were independent of CT-SES.
CONCLUSIONS
We found race/ethnicity to be more frequently associated with sarcoma incidence than CT-SES. Our findings suggest that genetic variation associated with ancestry may play a stronger role than area-level SES-related factors in the etiology of sarcoma.
IMPACT
These findings provide direction for future etiologic studies of sarcomas.
Identifiants
pubmed: 32928933
pii: 1055-9965.EPI-20-0520
doi: 10.1158/1055-9965.EPI-20-0520
pmc: PMC7641997
mid: NIHMS1625997
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2141-2148Subventions
Organisme : NIAMS NIH HHS
ID : T32 AR050938
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002494
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
Cancer. 2009 Aug 1;115(15):3526-36
pubmed: 19548262
Ecology. 2007 Nov;88(11):2766-72
pubmed: 18051645
AIDS. 1998 Dec 24;12(18):2481-8
pubmed: 9875587
Nat Genet. 2012 Feb 12;44(3):323-7
pubmed: 22327514
N Engl J Med. 2015 Dec 10;373(24):2336-2346
pubmed: 26580448
Lancet Oncol. 2016 Sep;17(9):1261-71
pubmed: 27498913
Oncologist. 2016 Aug;21(8):1002-13
pubmed: 27401891
Curr Protoc Hum Genet. 2017 Jul 11;94:1.23.1-1.23.8
pubmed: 28696560
Ann N Y Acad Sci. 2001 Dec;954:88-117
pubmed: 11797869
Int J Cancer. 2006 Feb 15;118(4):1017-21
pubmed: 16152578
Cancer. 2016 Nov 15;122(22):3492-3500
pubmed: 27481314
Cancer Med. 2015 May;4(5):781-90
pubmed: 25809884
JAMA Oncol. 2018 Sep 1;4(9):1293-1295
pubmed: 30098150
Anticancer Res. 2013 Jun;33(6):2597-604
pubmed: 23749914
Nat Rev Cancer. 2003 Sep;3(9):685-94
pubmed: 12951587
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):298-302
pubmed: 25277795
Cancer. 1985 Jun 15;55(12):2883-8
pubmed: 3857961
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10149-54
pubmed: 18626011
Annu Rev Genomics Hum Genet. 2010;11:65-89
pubmed: 20594047
Clin Sarcoma Res. 2012 Oct 04;2(1):18
pubmed: 23036235
Br J Cancer. 2007 Jun 4;96(11):1760-6
pubmed: 17505509
Genes Chromosomes Cancer. 2016 Apr;55(4):291-310
pubmed: 26684580
Eur J Cancer Prev. 2014 Nov;23(6):560-5
pubmed: 24356343
Pediatr Blood Cancer. 2011 Dec 1;57(6):943-9
pubmed: 21793180
Epidemiology. 2009 Jul;20(4):475-83
pubmed: 19373093
Int J Cancer. 2006 Dec 15;119(12):2922-30
pubmed: 17013893
Nat Genet. 2013 Jul;45(7):799-803
pubmed: 23727862
Cancer Epidemiol. 2016 Feb;40:39-46
pubmed: 26618334
Int J Cancer. 1988 Oct 15;42(4):511-20
pubmed: 3170025
J Natl Cancer Inst. 2015 Apr 20;107(7):
pubmed: 25896519
Sci Rep. 2017 Sep 6;7(1):10660
pubmed: 28878254
Environ Health. 2007 Jul 16;6:19
pubmed: 17634118
Cancer Causes Control. 2014 Jan;25(1):81-92
pubmed: 24178398
Br J Ind Med. 1981 Feb;38(1):27-33
pubmed: 7470401
Annu Rev Public Health. 1997;18:341-78
pubmed: 9143723
Br J Cancer. 2010 Jan 5;102(1):227-31
pubmed: 19997102
Sci Total Environ. 2017 Feb 1;579:1333-1342
pubmed: 27916304
Pediatr Blood Cancer. 2016 Feb;63(2):196-201
pubmed: 26193998
Virchows Arch. 2010 Feb;456(2):193-9
pubmed: 19787372
Cancer. 2019 Sep 1;125(17):2926-2934
pubmed: 31090929
Pediatr Blood Cancer. 2016 Feb;63(2):189-90
pubmed: 26505490
Br J Cancer. 1979 Jun;39(6):711-7
pubmed: 444410
Nat Commun. 2018 Aug 9;9(1):3184
pubmed: 30093639
Cancer Genet. 2012 Jun;205(6):304-12
pubmed: 22749036
Ann Oncol. 2012 Sep;23(9):2442-2449
pubmed: 22331640
Cancer. 2008 Aug 1;113(3):616-27
pubmed: 18618615
Cancer Causes Control. 2010 Jul;21(7):1139-45
pubmed: 20198506
Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):449-53
pubmed: 21212061
Sarcoma. 2009;2009:741975
pubmed: 19503800
Am J Epidemiol. 2018 May 1;187(5):982-991
pubmed: 29036606
Hum Genomics. 2015 Jan 07;9:1
pubmed: 25563503
Br J Cancer. 2010 Jun 29;103(1):136-42
pubmed: 20531410
Cancer Causes Control. 2001 Oct;12(8):703-11
pubmed: 11562110