Ocular involvement in coronavirus disease 2019 (COVID-19): a clinical and molecular analysis.
2019-nCoV
COVID-19
Coronavirus
Ocular
SARS-CoV-2
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
03
06
2020
accepted:
05
09
2020
pubmed:
16
9
2020
medline:
5
3
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Coronavirus disease 2019 (COVID-19) caused a global pandemic with millions infected worldwide. Little is known on the ocular involvement associated with the disease. The aim of this study was to assess the clinical and molecular ocular involvement among patients with confirmed COVID-19 admitted to a tertiary care facility. Consecutive patients admitted to the COVID-19 Ward of the Shamir Medical Center in Israel during March and April, 2020 were included. The control group included patients negative for COVID-19 admitted during a similar period to a different ward. Patients were examined by trained Ophthalmologists. SARS-CoV-2 conjunctival swab samples were obtained. Included were 48 patients, 16 with confirmed COVID-19 and 32 controls. Median patient age was 68.5 (interquartile range: 31.5, mean: 63 ± 21) years and 48% were male. Active conjunctival injection was present in three patients (19%) with COVID-19, compared to none in the controls (p = 0.034). Patients with COVID-19 were more likely to complain of foreign body sensation (31.3% vs 3.1%, p = 0.005) and redness of the eye (25% vs 0%, p = 0.003). Conjunctival injection was associated with loss of smell and taste (75% vs 7.7%, p = 0.018). Viral conjunctival swab tests all showed negative results for all three viral genes tested (E, N, and RdRp). Among patients admitted to a tertiary referral center with confirmed COVID-19, active conjunctival injection was noted in one out of five cases, and was associated with loss of smell and taste. Conjunctival swabs for viral RNA were negative in patients with and without ocular involvement.
Identifiants
pubmed: 32929665
doi: 10.1007/s10792-020-01592-1
pii: 10.1007/s10792-020-01592-1
pmc: PMC7489575
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
433-440Références
Li Q, Guan X, Wu P et al (2020) Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med 382(13):1199–1207. https://doi.org/10.1056/NEJMoa2001316
doi: 10.1056/NEJMoa2001316
pubmed: 31995857
pmcid: 7121484
Worldometer (2020) COVID-19 coronavirus pandemic. Worldometer. https://doi.org/10.1101/2020.01.23.20018549V2
doi: 10.1101/2020.01.23.20018549V2
World Health Organization: Coronavirus disease (COVID-19) technical guidance: Laboratory testing for 2019-nCoV in humans. Accessed 24 April 2020. https://doi.org/10.1080/00963402.1970.11457861
Guan W, Ni Z, Hu Y et al (2020) Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. https://doi.org/10.1056/nejmoa2002032
doi: 10.1056/nejmoa2002032
pubmed: 32220206
pmcid: 7121484
Wu P, Duan F, Luo C et al (2019) Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol. https://doi.org/10.1001/jamaophthalmol.2020.1291
doi: 10.1001/jamaophthalmol.2020.1291
pubmed: 31697330
pmcid: 6865304
Yu A-Y, Tu R, Shao X, Pan A, Zhou K, Huang J (2020) A comprehensive Chinese experience against SARS-CoV-2 in ophthalmology. Eye Vis 7(1):19. https://doi.org/10.1186/s40662-020-00187-2
doi: 10.1186/s40662-020-00187-2
Zhang X, Chen X, Chen L et al (2020) The evidence of SARS-CoV-2 infection on ocular surface. Ocul Surf. https://doi.org/10.1016/j.jtos.2020.03.010
doi: 10.1016/j.jtos.2020.03.010
pubmed: 32710961
pmcid: 7194535
Wei LC, Fen LX, Fang JZ (2020) 2019-nCoV transmission through the ocular surface must not be ignored. Lancet 395(10224):e39. https://doi.org/10.1016/S0140-6736(20)30313-5
doi: 10.1016/S0140-6736(20)30313-5
Zhou Y, Zeng Y, Tong Y, Chen C (2020) Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva. medRxiv. https://doi.org/10.1101/2020.02.11.20021956
Seah I, Agrawal R (2020) Can the coronavirus disease 2019 (COVID-19) affect the eyes? A review of coronaviruses and ocular implications in humans and animals. Ocul Immunol Inflamm 28(3):391–395. https://doi.org/10.1080/09273948.2020.1738501
doi: 10.1080/09273948.2020.1738501
pubmed: 32175797
Patel A, Jernigan DB, Abdirizak F et al (2020) Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak—United States, December 31, 2019–February 4, 2020. Am J Transplant 20(3):889–895. https://doi.org/10.1111/ajt.15805
doi: 10.1111/ajt.15805
pubmed: 32745377
pmcid: 7159597
Lai THT, Tang EWH, Chau SKY, Fung KSC, Li KKW (2020) Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong. Graefe’s Arch Clin Exp Ophthalmol. https://doi.org/10.1007/s00417-020-04641-8
doi: 10.1007/s00417-020-04641-8
Song C-Y, Xu J, He J-Q, Lu Y-Q (2020) COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients. medRxiv. https://doi.org/10.1101/2020.03.05.20031906
Chen L, Liu M, Zhang Z et al (2020) Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. https://doi.org/10.1136/bjophthalmol-2020-316304
doi: 10.1136/bjophthalmol-2020-316304
pubmed: 33355150
pmcid: 7788223
Xia J, Tong J, Liu M, Shen Y, Guo D (2020) Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol. https://doi.org/10.1002/jmv.25725
doi: 10.1002/jmv.25725
pubmed: 33289151
pmcid: 7821149
Ulhaq ZS, Soraya GV (2020) The prevalence of ophthalmic manifestations in COVID-19 and the diagnostic value of ocular tissue/fluid. Graefe’s Arch Clin Exp Ophthalmol. https://doi.org/10.1007/s00417-020-04695-8
doi: 10.1007/s00417-020-04695-8
Yu Jun IS, Anderson DE, Zheng Kang AE et al (2020) Assessing viral shedding and infectivity of tears in coronavirus disease 2019 (COVID-19) patients. Ophthalmology. https://doi.org/10.1016/j.ophtha.2020.03.026
doi: 10.1016/j.ophtha.2020.03.026
Gautier JF, Ravussin Y (2020) A new symptom of COVID-19: loss of taste and smell. Obesity. https://doi.org/10.1002/oby.22809
doi: 10.1002/oby.22809
pubmed: 32237199
Vaira LA, Salzano G, Deiana G, De Riu G (2020) Anosmia and ageusia: common findings in COVID-19 patients. Laryngoscope. https://doi.org/10.1002/lary.28692
doi: 10.1002/lary.28692
pubmed: 32678494
pmcid: 7405289
Neri P, Pichi F (2020) COVID-19 and the eye immunity: lesson learned from the past and possible new therapeutic insights. Int Ophthalmol 40(5):1057–1060. https://doi.org/10.1007/s10792-020-01389-2
doi: 10.1007/s10792-020-01389-2
pubmed: 32314322