Laser Treatment for Non-Melanoma Skin Cancer: A Systematic Review and Meta-Analysis.
Biopsy
Bowen's Disease
/ diagnosis
Carcinoma, Basal Cell
/ diagnosis
Cicatrix
/ epidemiology
Cohort Studies
Follow-Up Studies
Humans
Hypopigmentation
/ epidemiology
Laser Therapy
/ adverse effects
Lasers, Dye
/ adverse effects
Lasers, Gas
/ adverse effects
Lasers, Solid-State
/ adverse effects
Neoplasm Recurrence, Local
/ diagnosis
Neoplasm, Residual
Randomized Controlled Trials as Topic
Skin
/ pathology
Skin Neoplasms
/ diagnosis
Skin Pigmentation
/ radiation effects
Treatment Outcome
Journal
American journal of clinical dermatology
ISSN: 1179-1888
Titre abrégé: Am J Clin Dermatol
Pays: New Zealand
ID NLM: 100895290
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
pubmed:
16
9
2020
medline:
29
6
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Surgery is the mainstay of treatment for non-melanoma skin cancer. Lasers are an additional option. The objective of this study was to review the literature on the efficacy and safety of lasers for the treatment of non-melanoma skin cancer. A systematic review and meta-analysis of laser treatment for non-melanoma skin cancer was performed. The primary outcome was recurrence rate (RR). The review included 32 studies (six randomized controlled trials and 26 cohort studies): 27 evaluated basal cell carcinomas (BCCs), three squamous cell carcinomas, and two both, for a total of 4755 BCCs and 214 squamous cell carcinoas. Most BCCs were low risk. The Nd:YAG laser (seven studies, 3286 BCCs) had a 3.1% RR (95% confidence interval [CI] 1.4-6.4%) during a mean follow-up of 7.9 years, with a low rate (< 20%) of scarring and dyspigmentation. The CO Based on cohort studies, the Nd:YAG laser is a safe and efficacious modality for the treatment of low-risk BCC. Based on settings applied in prior studies in the literature, the CO PROSPERO registration number CRD42019129717.
Sections du résumé
BACKGROUND
BACKGROUND
Surgery is the mainstay of treatment for non-melanoma skin cancer. Lasers are an additional option.
OBJECTIVE
OBJECTIVE
The objective of this study was to review the literature on the efficacy and safety of lasers for the treatment of non-melanoma skin cancer.
METHODS
METHODS
A systematic review and meta-analysis of laser treatment for non-melanoma skin cancer was performed. The primary outcome was recurrence rate (RR).
RESULTS
RESULTS
The review included 32 studies (six randomized controlled trials and 26 cohort studies): 27 evaluated basal cell carcinomas (BCCs), three squamous cell carcinomas, and two both, for a total of 4755 BCCs and 214 squamous cell carcinoas. Most BCCs were low risk. The Nd:YAG laser (seven studies, 3286 BCCs) had a 3.1% RR (95% confidence interval [CI] 1.4-6.4%) during a mean follow-up of 7.9 years, with a low rate (< 20%) of scarring and dyspigmentation. The CO
CONCLUSIONS
CONCLUSIONS
Based on cohort studies, the Nd:YAG laser is a safe and efficacious modality for the treatment of low-risk BCC. Based on settings applied in prior studies in the literature, the CO
REGISTRATION
BACKGROUND
PROSPERO registration number CRD42019129717.
Identifiants
pubmed: 32930983
doi: 10.1007/s40257-020-00562-8
pii: 10.1007/s40257-020-00562-8
doi:
Types de publication
Evaluation Study
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-38Références
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