Long-Term Mortality Among ICU Patients With Stroke Compared With Other Critically Ill Patients.
Adult
Age Factors
Aged
Aged, 80 and over
Comorbidity
Critical Illness
/ mortality
Glasgow Coma Scale
Hemorrhagic Stroke
/ mortality
Humans
Intensive Care Units
/ statistics & numerical data
Ischemic Stroke
/ mortality
Middle Aged
Netherlands
/ epidemiology
Regression Analysis
Risk Factors
Sex Factors
Socioeconomic Factors
Stroke
/ mortality
Journal
Critical care medicine
ISSN: 1530-0293
Titre abrégé: Crit Care Med
Pays: United States
ID NLM: 0355501
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
26
5
2021
Statut:
ppublish
Résumé
Assessment of all-cause mortality of intracerebral hemorrhage and ischemic stroke patients admitted to the ICU and comparison to the mortality of other critically ill ICU patients classified into six other diagnostic subgroups and the general Dutch population. Observational cohort study. All ICUs participating in the Dutch National Intensive Care Evaluation database. All adult patients admitted to these ICUs between 2010 and 2015; patients were followed until February 2017. None. Of all 370,386 included ICU patients, 7,046 (1.9%) were stroke patients, 4,072 with ischemic stroke, and 2,974 with intracerebral hemorrhage. Short-term mortality in ICU-admitted stroke patients was high with 30 days mortality of 31% in ischemic stroke and 42% in intracerebral hemorrhage. In the longer term, the survival curve gradient among ischemic stroke and intracerebral hemorrhage patients stabilized. The gradual alteration of mortality risk after ICU admission was assessed using left-truncation with increasing minimum survival period. ICU-admitted stroke patients who survive the first 30 days after suffering from a stroke had a favorable subsequent survival compared with other diseases necessitating ICU admission such as patients admitted due to sepsis or severe community-acquired pneumonia. After having survived the first 3 months after ICU admission, multivariable Cox regression analyses showed that case-mix adjusted hazard ratios during the follow-up period of up to 3 years were lower in ischemic stroke compared with sepsis (adjusted hazard ratio, 1.21; 95% CI, 1.06-1.36) and severe community-acquired pneumonia (adjusted hazard ratio, 1.57; 95% CI, 1.39-1.77) and in intracerebral hemorrhage patients compared with these groups (adjusted hazard ratio, 1.14; 95% CI, 0.98-1.33 and adjusted hazard ratio, 1.49; 95% CI, 1.28-1.73). Stroke patients who need intensive care treatment have a high short-term mortality risk, but this alters favorably with increasing duration of survival time after ICU admission in patients with both ischemic stroke and intracerebral hemorrhage, especially compared with other populations of critically ill patients such as sepsis or severe community-acquired pneumonia patients.
Identifiants
pubmed: 32931193
doi: 10.1097/CCM.0000000000004492
pii: 00003246-202010000-00030
doi:
Banques de données
NTR
['NTR7438']
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e876-e883Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Références
Rothwell PM, Coull AJ, Giles MF, et al.; Oxford Vascular Study: Change in stroke incidence, mortality, case-fatality, severity, and risk factors in Oxfordshire, UK from 1981 to 2004 (Oxford Vascular Study). Lancet 2004; 363:1925–1933
StatLine Database of the Dutch Governmental Institution Statistics Netherlands (Centraal Bureau voor de Statistiek (CBS)).Available at: http://statline.cbs.nl/Statweb/. Accessed November 1, 2018
Kochanek KD, Murphy S, Xu J, et al. Mortality in the United States, 2016. NCHS Data Brief 2017:1–8
Benjamin EJ, Blaha MJ, Chiuve SE, et al.; American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics-2017 update: A report from the American Heart Association. Circulation 2017; 135:e146–e603
Kirkman MA, Citerio G, Smith M. The intensive care management of acute ischemic stroke: An overview. Intensive Care Med 2014; 40:640–653
Llinas RH. Ischemic stroke and ICU care. Semin Neurol 2008; 28:645–656
Sacco RL, Kasner SE, Broderick JP, et al.; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism: An updated definition of stroke for the 21st century: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44:2064–2089
Nieuwkamp DJ, de Wilde A, Wermer MJ, et al. Long-term outcome after aneurysmal subarachnoid hemorrhage-risks of vascular events, death from cancer and all-cause death. J Neurol 2014; 261:309–315
Pinnamaneni S, Aronow WS, Frishman WH. Neurocardiac injury after cerebral and subarachnoid hemorrhages. Cardiol Rev 2017; 25:89–95
Navarrete-Navarro P, Rivera-Fernández R, López-Mutuberría MT, et al. Outcome prediction in terms of functional disability and mortality at 1 year among ICU-admitted severe stroke patients: A prospective epidemiological study in the south of the European Union (Evascan Project, Andalusia, Spain). Intensive Care Med 2003; 29:1237–1244
Handschu R, Haslbeck M, Hartmann A, et al. Mortality prediction in critical care for acute stroke: Severity of illness-score or coma-scale? J Neurol 2005; 252:1249–1254
Broessner G, Helbok R, Lackner P, et al. Survival and long-term functional outcome in 1,155 consecutive neurocritical care patients. Crit Care Med 2007; 35:2025–2030
Kiphuth IC, Schellinger PD, Köhrmann M, et al. Predictors for good functional outcome after neurocritical care. Crit Care 2010; 14:R136
Pelosi P, Ferguson ND, Frutos-Vivar F, et al.; Ventila Study Group: Management and outcome of mechanically ventilated neurologic patients. Crit Care Med 2011; 39:1482–1492
Alonso A, Ebert AD, Kern R, et al. Outcome predictors of acute stroke patients in need of intensive care treatment. Cerebrovasc Dis 2015; 40:10–17
Dutch National Intensive Care Evaluation (NICE) Foundation.Available at: http://www.stichting-nice.nl. Accessed November 1, 2018
Brinkman S, de Jonge E, Abu-Hanna A, et al. Mortality after hospital discharge in ICU patients. Crit Care Med 2013; 41:1229–1236
Broderick JP, Palesch YY, Demchuk AM, et al.; Interventional Management of Stroke (IMS) III Investigators: Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med 2013; 368:893–903
Ciccone A, Valvassori L, Nichelatti M, et al.; SYNTHESIS Expansion Investigators: Endovascular treatment for acute ischemic stroke. N Engl J Med 2013; 368:904–913
Kidwell CS, Jahan R, Gornbein J, et al.; MR RESCUE Investigators: A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med 2013; 368:914–923
Berkhemer OA, Fransen PS, Beumer D, et al.; MR CLEAN Investigators: A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med 2015; 372:11–20
Goyal M, Demchuk AM, Menon BK, et al.; ESCAPE Trial Investigators: Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med 2015; 372:1019–1030
Prabhakaran S, Ruff I, Bernstein RA. Acute stroke intervention: A systematic review. JAMA 2015; 313:1451–1462
Goyal M, Menon BK, van Zwam WH, et al.; HERMES collaborators: Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-analysis of individual patient data from five randomised trials. Lancet 2016; 387:1723–1731
Roos LL, Wajda A. Record linkage strategies. Part I: Estimating information and evaluating approaches. Methods Inf Med 1991; 30:117–123
Zimmerman JE, Kramer AA, McNair DS, et al. Acute Physiology and Chronic Health Evaluation (APACHE) IV: Hospital mortality assessment for today’s critically ill patients. Crit Care Med 2006; 34:1297–1310
Nederlandse Vereniging voor Neurologie (Dutch Society for Neurology): Specialisten KVMS Richtlijn herseninfarct en hersenbloeding. Utrecht, The Netherlands, Nederlandse Vereniging voor Neurologie (Dutch Society for Neurology)2017, pp 1–318. Available at: https://nvic.nl/sites/nvic.nl/files/Richtlijnen aanmaken/Richtlijnherseninfarct en hersenbloeding.pdf. Accessed September 10, 2019
Jeng JS, Huang SJ, Tang SC, et al. Predictors of survival and functional outcome in acute stroke patients admitted to the stroke intensive care unit. J Neurol Sci 2008; 270:60–66
Riachy M, Sfeir F, Sleilaty G, et al. Prediction of the survival and functional ability of severe stroke patients after ICU therapeutic intervention. BMC Neurol 2008; 8:24
van Valburg MK, Arbous MS, Georgieva M, et al. Clinical predictors of survival and functional outcome of stroke patients admitted to critical care. Crit Care Med 2018; 46:1085–1092
de Vries VA, Müller MCA, Sesmu Arbous M, et al.; HEMA-ICU Study Group: Time trend analysis of long term outcome of patients with haematological malignancies admitted at Dutch intensive care units. Br J Haematol 2018; 181:68–76
Linder A, Lee T, Fisher J, et al. Short-term organ dysfunction is associated with long-term (10-yr) mortality of septic shock. Crit Care Med 2016; 44:e728–e736
Schuler A, Wulf DA, Lu Y, et al. The impact of acute organ dysfunction on long-term survival in sepsis. Crit Care Med 2018; 46:843–849
Shankar-Hari M, Rubenfeld GD. Understanding long-term outcomes following sepsis: Implications and challenges. Curr Infect Dis Rep2016; 18:37
Prescott HC, Angus DC. Enhancing recovery from sepsis: A review. JAMA 2018; 319:62–75
Brinkman S, Bakhshi-Raiez F, Abu-Hanna A, et al. External validation of Acute Physiology and Chronic Health Evaluation IV in Dutch intensive care units and comparison with Acute Physiology and Chronic Health Evaluation II and Simplified Acute Physiology Score II. J Crit Care 2011; 26:105.e11–e18
Brinkman S, Bakhshi-Raiez F, Abu-Hanna A, et al. Determinants of mortality after hospital discharge in ICU patients: Literature review and Dutch cohort study. Crit Care Med 2013; 41:1237–1251
Dutch Institute for Clinical Auditing (DICA): Dutch Acute Stroke Audit (DASA) As Part of the Dutch Institute for Clinical Auditing (DICA).2017Available at: https://dica.nl/jaarrapportage-2017/dasa. Accessed February 1, 2019
Lyden P, Brott T, Tilley B, et al. Improved reliability of the NIH Stroke Scale using video training. NINDS TPA Stroke Study Group. Stroke1994; 25:2220–2226
National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 1995; 333:1581–1587
Besmertis C, Manley GT, Johnston SC. The ICH score. Stroke 2001; 32:891–897
Tromp M, Ravelli AC, Bonsel GJ, et al. Results from simulated data sets: Probabilistic record linkage outperforms deterministic record linkage. J Clin Epidemiol 2011; 64:565–572