Manganese-enhanced MRI (MEMRI) in breast and prostate cancers: Preliminary results exploring the potential role of calcium receptors.
Animals
Breast Neoplasms
/ diagnostic imaging
Calcium
/ metabolism
Cell Line, Tumor
Chlorides
/ administration & dosage
Contrast Media
/ administration & dosage
Feasibility Studies
Female
Humans
Immunohistochemistry
Injections, Intravenous
Magnetic Resonance Imaging
/ methods
Male
Manganese Compounds
/ administration & dosage
Mice
Pilot Projects
Prostatic Neoplasms
/ diagnostic imaging
Receptors, Calcium-Sensing
/ metabolism
TRPV Cation Channels
/ metabolism
Tissue Distribution
Xenograft Model Antitumor Assays
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
10
2019
accepted:
12
08
2020
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
28
10
2020
Statut:
epublish
Résumé
To preliminary assess the relationship between Manganese Enhanced Magnetic Resonance Imaging (MEMRI) and the expression of calcium receptors in human prostate and breast cancer animal models. NOD/SCID mice were inoculated with MDA-MB-231 breast cancer cells and prostate PC3 cancer cells to develop orthotopic or pseudometastatic cancer animal models. Mice were studied on a clinical 3T scanner by using a prototype birdcage coil before and after intravenous injection of MnCl2. Assessment of receptor's status was carried out after the MR images acquisition by immunohistochemistry on excised tumours. Manganese contrast enhancement in breast or prostate cancer animal models well correlated with CaSR expression (p<0.01), whereas TRPV6 expression levels appeared not relevant to the Mn uptake. Our preliminary results suggest that MEMRI appears an efficient tool to characterize human breast and prostate cancer animal models in the presence of different expression level of calcium receptors.
Identifiants
pubmed: 32931488
doi: 10.1371/journal.pone.0224414
pii: PONE-D-19-28343
pmc: PMC7491733
doi:
Substances chimiques
Chlorides
0
Contrast Media
0
Manganese Compounds
0
Receptors, Calcium-Sensing
0
TRPV Cation Channels
0
TRPV6 channel
0
manganese chloride
QQE170PANO
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0224414Déclaration de conflit d'intérêts
The author(s) declare no competing interests. All of the authors are aware of and agree to the content of the paper, as well as to their being listed as authors. None of the material has been published or is under consideration elsewhere, including the Internet. We also declare that none of the authors had any prior discussions with a Plos One Editorial Board Member about the work here described in the manuscript.
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