Mesenchymal stem cell tailored bioengineered scaffolds derived from bubaline diaphragm and aortic matrices for reconstruction of abdominal wall defects.
Abdominal Wall
/ pathology
Adipogenesis
Animals
Aorta
/ physiology
Bioengineering
Biomechanical Phenomena
Buffaloes
Cattle
Cell Lineage
Chondrogenesis
Collagen
/ metabolism
DNA
/ metabolism
Diaphragm
/ physiology
Extracellular Matrix
/ metabolism
Implants, Experimental
Mesenchymal Stem Cells
/ cytology
Osteogenesis
Rabbits
Regeneration
/ physiology
Sodium Dodecyl Sulfate
Tissue Adhesions
/ pathology
Tissue Scaffolds
/ chemistry
Water
abdominal wall defects
aortic matrices
bubaline
diaphragm
mesenchymal stem cell
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
29
06
2020
revised:
01
09
2020
accepted:
01
09
2020
pubmed:
16
9
2020
medline:
15
10
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Bioengineered scaffolds derived from the decellularized extracellular matrix (ECM) obtained from discarded animal organs and tissues are attractive candidates for regenerative medicine applications. Tailoring these scaffolds with stem cells enhances their regeneration potential making them a suitable platform for regenerating damaged tissues. Thus, the study was designed to investigate the potential of mesenchymal stem cells tailored acellular bubaline diaphragm and aortic ECM for the repair of full-thickness abdominal wall defects in a rabbit model. Tissues obtained from bubaline diaphragm and aorta were decellularized and bioengineered by seeding with rabbit bone marrow derived mesenchymal stem cells (r-BMSC). Full-thickness abdominal wall defects of 3 cm × 4 cm size were created in a rabbit model and repaired using five different prostheses, namely, polypropylene sheet, nonseeded diaphragm ECM, nonseeded aorta ECM, r-BMSC bioengineered diaphragm ECM, and r-BMSC bioengineered aorta ECM. Results from the study revealed that biological scaffolds are superior in comparison to synthetic polymer mesh for regeneration in terms of collagen deposition, maturation, neovascularization, and lack of any significant (P > 0.05) adhesions with the abdominal viscera. Seeding with r-BMSC significantly increased (P < 0.05) the collagen deposition and biomechanical strength of the scaffolds. The bioengineered r-BMSC seeded acellular bubaline diaphragm showed even superior biomechanical strength as compared to synthetic polymer mesh. Tailoring of the scaffolds with the r-BMSC also resulted in significant reduction (P < 0.01) in antibody and cell mediated immune reactions to the xenogeneic scaffolds in rabbit model.
Substances chimiques
Water
059QF0KO0R
Sodium Dodecyl Sulfate
368GB5141J
Collagen
9007-34-5
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1763-1778Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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