Sensory Experience Engages Microglia to Shape Neural Connectivity through a Non-Phagocytic Mechanism.
dendritic spine
development
microglia
pruning
sensory experience
synapse
synaptic refinement
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
11 11 2020
11 11 2020
Historique:
received:
22
07
2019
revised:
10
05
2020
accepted:
05
08
2020
pubmed:
16
9
2020
medline:
29
12
2020
entrez:
15
9
2020
Statut:
ppublish
Résumé
Sensory experience remodels neural circuits in the early postnatal brain through mechanisms that remain to be elucidated. Applying a new method of ultrastructural analysis to the retinogeniculate circuit, we find that visual experience alters the number and structure of synapses between the retina and the thalamus. These changes require vision-dependent transcription of the receptor Fn14 in thalamic relay neurons and the induction of its ligand TWEAK in microglia. Fn14 functions to increase the number of bulbous spine-associated synapses at retinogeniculate connections, likely contributing to the strengthening of the circuit that occurs in response to visual experience. However, at retinogeniculate connections near TWEAK-expressing microglia, TWEAK signals via Fn14 to restrict the number of bulbous spines on relay neurons, leading to the elimination of a subset of connections. Thus, TWEAK and Fn14 represent an intercellular signaling axis through which microglia shape retinogeniculate connectivity in response to sensory experience.
Identifiants
pubmed: 32931754
pii: S0896-6273(20)30609-7
doi: 10.1016/j.neuron.2020.08.002
pmc: PMC7666095
mid: NIHMS1620438
pii:
doi:
Substances chimiques
Cytokine TWEAK
0
TWEAK Receptor
0
Tnfrsf12a protein, mouse
0
Tnfsf12 protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
451-468.e9Subventions
Organisme : NIMH NIH HHS
ID : R00 MH120051
Pays : United States
Organisme : NIMH NIH HHS
ID : RF1 MH114047
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS072030
Pays : United States
Organisme : NIMH NIH HHS
ID : K99 MH120051
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS085320
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS028829
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY012196
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests L.C.B. and K.A.E. are employees and shareholders of Biogen.