Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.

Acute Lung Injury / chemically induced Alkenes / pharmacology Animals Bleomycin Bronchoalveolar Lavage Fluid Fatty Acids / pharmacology Inflammation / chemically induced Leukocyte Common Antigens / metabolism Lung / pathology Macrophages, Alveolar / drug effects Male Mesenchymal Stem Cells / drug effects Mice Mice, Inbred C57BL Phospholipids / metabolism Weight Loss / drug effects Zinc Finger E-box-Binding Homeobox 1 / biosynthesis
Acute Lung Injury Bleomycin Inflammation Macrophage Nitro-Oleic Acid Nitroalkene

Journal

Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575

Informations de publication

Date de publication:
15 11 2020
Historique:
received: 20 04 2020
revised: 03 08 2020
accepted: 08 09 2020
pubmed: 16 9 2020
medline: 9 1 2021
entrez: 15 9 2020
Statut: ppublish

Résumé

Fatty acid nitroalkenes are reversibly-reactive electrophiles, endogenously detectable at nM concentrations, displaying anti-inflammatory actions. Nitroalkenes like 9- or 10-nitro-octadec-9-enoic acid (e.g. nitro-oleic acid, OA-NO

Identifiants

DOI: 10.1016/j.taap.2020.115236 PMID: 32931793 PMC: PMC7662837
pubmed: 32931793
pii: S0041-008X(20)30362-8
doi: 10.1016/j.taap.2020.115236
pmc: PMC7662837
mid: NIHMS1628762
pii:
doi:

Substances chimiques

Alkenes 0
Fatty Acids 0
Phospholipids 0
ZEB1 protein, mouse 0
Zinc Finger E-box-Binding Homeobox 1 0
Bleomycin 11056-06-7
Leukocyte Common Antigens EC 3.1.3.48

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

115236

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL086621
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132550
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL064937
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL103455
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007148
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

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Auteurs

Melissa L Wilkinson (ML)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Elena Abramova (E)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Changjiang Guo (C)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.

James G Gow (JG)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Dartmouth College, Hanover, NH 03755, USA.

Alexa Murray (A)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.

Adolf Koudelka (A)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.

Veronika Cechova (V)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.

Bruce A Freeman (BA)

Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.

Andrew J Gow (AJ)

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA. Electronic address: gow@pharmacy.rutgers.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Lésion pulmonaire aigüe › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcènes › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Eucaryotes › Animaux › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Bléomycine › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Lipides › Acides gras › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Receptor-Like Protein Tyrosine Phosphatases › Receptor-Like Protein Tyrosine Phosphatases, Class 1 › Antigènes CD45 › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Appareil respiratoire › Poumon › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Mensurations corporelles › Poids › Modifications du poids corporel › Perte de poids › Fatty acid nitroalkenes inhibit the...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines de répression › Facteur de transcription Zeb1 › Fatty acid nitroalkenes inhibit the...