Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects.
Blood pressure
Heart rate variability
Oxidative stress
Renal injury
Vasoconstriction
Vasodilation
Journal
Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
received:
15
07
2020
revised:
27
08
2020
accepted:
09
09
2020
pubmed:
16
9
2020
medline:
12
1
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Hydraulic fracturing is used to access oil and natural gas reserves. This process involves the high-pressure injection of fluid to fracture shale. Fracking fluid contains approximately 95% water, chemicals and 4.5% fracking sand. Workers may be exposed to fracking sand dust (FSD) during the manipulation of the sand, and negative health consequences could occur if FSD is inhaled. In the absence of any information about its potential toxicity, a comprehensive rat animal model study (see Fedan et al., 2020) was designed to investigate the bioactivities of several FSDs in comparison to MIN-U-SIL® 5, a respirable α-quartz reference dust used in previous animal models of silicosis, in several organ systems. The goal of this study was to assess the effects of inhalation of one FSD, i.e., FSD 8, on factors and tissues that affect cardiovascular function. Male rats were exposed to 10 or 30 mg/m
Identifiants
pubmed: 32931794
pii: S0041-008X(20)30368-9
doi: 10.1016/j.taap.2020.115242
pmc: PMC7673239
mid: NIHMS1640439
pii:
doi:
Substances chimiques
Dust
0
Nitrates
0
Nitrites
0
Sand
0
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
115242Subventions
Organisme : Intramural CDC HHS
ID : CC999999
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM104942
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflicts of interest in relation to this publication.
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