Etoposide as Salvage Therapy for Cytokine Storm Due to Coronavirus Disease 2019.

Aged COVID-19 / complications Cytokine Release Syndrome / drug therapy Etoposide / therapeutic use Female Humans Salvage Therapy / methods Severity of Illness Index
COVID-19 etoposide

Journal

Chest
ISSN: 1931-3543
Titre abrégé: Chest
Pays: United States
ID NLM: 0231335

Informations de publication

Date de publication:
01 2021
Historique:
received: 04 05 2020
revised: 21 08 2020
accepted: 07 09 2020
pubmed: 16 9 2020
medline: 29 1 2021
entrez: 15 9 2020
Statut: ppublish

Résumé

Coronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.

Identifiants

DOI: 10.1016/j.chest.2020.09.077 PMID: 32931823 PMC: PMC7486855
pubmed: 32931823
pii: S0012-3692(20)34486-X
doi: 10.1016/j.chest.2020.09.077
pmc: PMC7486855
pii:
doi:

Substances chimiques

Etoposide 6PLQ3CP4P3

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e7-e11

Commentaires et corrections

Type : CommentIn
Type : CommentIn

Informations de copyright

Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

Références

Tidsskr Nor Laegeforen. 2020 Mar 23;140(6):
pubmed: 32321221
Lancet. 2010 Dec 18;376(9758):2116
pubmed: 21168053
Zhonghua Shao Shang Za Zhi. 2020 Jun 20;36(6):471-475
pubmed: 32114747
J Pharm Anal. 2020 Apr;10(2):102-108
pubmed: 32282863
Chest. 2016 May;149(5):1294-301
pubmed: 26836913
Int J Hematol. 2020 Jul;112(1):122-124
pubmed: 32399895
Med Hypotheses. 2020 Nov;144:110180
pubmed: 33254502
Lancet. 2006 Mar 11;367(9513):870-3
pubmed: 16530581
J Immunol. 2014 Jan 1;192(1):84-91
pubmed: 24259502
Clin Exp Immunol. 2004 Apr;136(1):95-103
pubmed: 15030519
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
Autoimmun Rev. 2020 Jul;19(7):102554
pubmed: 32380316
Haematologica. 2015 Aug;100(8):997-1004
pubmed: 26314082
JAMA. 2020 Aug 4;324(5):460-470
pubmed: 32492084
Lancet. 2020 Mar 28;395(10229):1033-1034
pubmed: 32192578
Blood. 2017 Dec 21;130(25):2728-2738
pubmed: 28935695

Auteurs

Maulin Patel (M)

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Electronic address: maulin.patel@tuhs.temple.edu.

Eduardo Dominguez (E)

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Daniel Sacher (D)

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Parag Desai (P)

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Ashwin Chandar (A)

Department of Hematology and Oncology, Temple University Hospital, Philadelphia, PA.

Michael Bromberg (M)

Department of Hematology and Oncology, Temple University Hospital, Philadelphia, PA.

Roberto Caricchio (R)

Department of Rheumatology, Temple University Hospital, Philadelphia, PA.

Gerard J Criner (GJ)

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Syndrome de libération de cytokines › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › Glucides › Hétérosides › Glucosides › Étoposide › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › Thérapeutique › Thérapie de rattrapage › Etoposide as Salvage Therapy for Cytokine...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Etoposide as Salvage Therapy for Cytokine...