Intraindividual Consistency of Iodine Concentration in Dual-Energy Computed Tomography of the Chest and Abdomen.
Journal
Investigative radiology
ISSN: 1536-0210
Titre abrégé: Invest Radiol
Pays: United States
ID NLM: 0045377
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
pubmed:
16
9
2020
medline:
16
10
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Dual-energy computed tomography (DECT)-derived quantification of iodine concentration (IC) is increasingly used in oncologic imaging to characterize lesions and evaluate treatment response. However, only limited data are available on intraindividual consistency of IC and its variation. This study investigates the longitudinal reproducibility of IC in organs, vessels, and lymph nodes in a large cohort of healthy patients who underwent repetitive DECT imaging. A total of 159 patients, who underwent a total of 469 repetitive (range, 2-4), clinically indicated portal-venous phase DECT examinations of the chest and abdomen, were retrospectively included. At time of imaging, macroscopic tumor burden was excluded by follow-up imaging (≥3 months). Iodine concentration was measured region of interest-based (N = 43) in parenchymatous organs, vessels, lymph nodes, and connective tissue. Normalization of IC to the aorta and to the trigger delay as obtained from bolus tracking was performed. For statistical analysis, intraclass correlation coefficient and modified variation coefficient (MVC) were used to assess intraindividual agreement of IC and its variation between different time points, respectively. Furthermore, t tests and analysis of variance with Tukey-Kramer post hoc test were used. The mean intraclass correlation coefficient over all regions of interest was good to excellent (0.642-0.936), irrespective of application of normalization or the normalization technique. Overall, MVC ranged from 1.8% to 25.4%, with significantly lower MVC in data normalized to the aorta (5.8% [1.8%-15.8%]) in comparison with the MVC of not normalized data and data normalized to the trigger delay (P < 0.01 and P = 0.04, respectively). Our study confirms intraindividual, longitudinal variation of DECT-derived IC, which varies among vessels, lymph nodes, organs, and connective tissue, following different perfusion characteristics; normalizing to the aorta seems to improve reproducibility when using a constant contrast media injection protocol.
Identifiants
pubmed: 32932376
pii: 00004424-202103000-00007
doi: 10.1097/RLI.0000000000000724
doi:
Substances chimiques
Contrast Media
0
Iodine
9679TC07X4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-187Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest and sources of funding: This work was partly funded through the Else Kröner-Fresenius-Stiftung (2018_EKMS.34 to Nils Große Hokamp). C.H. is an employee of MintMedical GmbH. S.L. received research support from Philips Healthcare. D.Z. received exemption from clinical duties for research outside this project as a part of a research agreement between Philips Healthcare and University Hospital Cologne. N.G.H. receives research support from Philips Healthcare. N.G.H. is on the speaker's bureau of Philips Healthcare.
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