Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule-Purkinje Neuron Synaptic Strength.

Animals Ataxin-2 / genetics Calcium Signaling / genetics Calcium-Binding Proteins / genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 / genetics Cells, Cultured Cerebellum / physiology Down-Regulation / genetics Mice Mice, Knockout Purkinje Cells / physiology RNA, Messenger / genetics Synapses / genetics
K-homology RNA-binding domain amyotrophic lateral sclerosis (ALS) fragile-X-associated tremor-ataxia syndrome fronto-temporal-lobar-dementia inositol signaling long-term potentiation neurexin spatial learning synaptic plasticity tauopathies

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
12 Sep 2020
Historique:
received: 20 08 2020
revised: 07 09 2020
accepted: 10 09 2020
entrez: 16 9 2020
pubmed: 17 9 2020
medline: 26 2 2021
Statut: epublish

Résumé

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca

Identifiants

DOI: 10.3390/ijms21186673 PMID: 32932600 PMC: PMC7555182
pubmed: 32932600
pii: ijms21186673
doi: 10.3390/ijms21186673
pmc: PMC7555182
pii:
doi:

Substances chimiques

Ataxin-2 0
Atxn2 protein, mouse 0
Calcium-Binding Proteins 0
RNA, Messenger 0
Calcium-Calmodulin-Dependent Protein Kinase Type 2 EC 2.7.11.17

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : AU96/11-1, AU96/11-3, FR3420/2-2, INST1172/37-1

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Auteurs

Aleksandar Arsović (A)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Melanie Vanessa Halbach (MV)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Júlia Canet-Pons (J)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Dilhan Esen-Sehir (D)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Medical Faculty, Goethe University, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt am Main, Germany.
Faculty of Biosciences, Goethe-University, Max von Laue Strasse 9, 60438 Frankfurt am Main, Germany.
ORCID: 0000-0002-4032-8807

Claudia Döring (C)

Dr. Senckenberg Institute of Pathology, Goethe University Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Florian Freudenberg (F)

Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Medical Faculty, Goethe University, Heinrich-Hoffmann-Str. 10, 60528 Frankfurt am Main, Germany.
ORCID: 0000-0003-1438-3850

Nicoletta Czechowska (N)

Institute of Anatomy, Anatomy and Cell Biology, University of Bonn, Nussallee 10, 53115 Bonn, Germany.

Kay Seidel (K)

Institute of Anatomy, Anatomy and Cell Biology, University of Bonn, Nussallee 10, 53115 Bonn, Germany.

Stephan L Baader (SL)

Institute of Anatomy, Anatomy and Cell Biology, University of Bonn, Nussallee 10, 53115 Bonn, Germany.

Suzana Gispert (S)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

Nesli-Ece Sen (NE)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.
Faculty of Biosciences, Goethe-University, Max von Laue Strasse 9, 60438 Frankfurt am Main, Germany.

Georg Auburger (G)

Experimental Neurology, Medical Faculty, Goethe University, Theodor Stern Kai 7, 60590 Frankfurt am Main, Germany.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Protéines de liaison au poly(A) › Ataxine-2 › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison au calcium › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Calcium-Calmodulin-Dependent Protein Kinases › Calcium-Calmodulin-Dependent Protein Kinase Type 2 › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Cellules › Cellules cultivées › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Rhombencéphale › Métencéphale › Cervelet › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation négative › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Cellules › Neurones › Cellules de Purkinje › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Mouse Ataxin-2 Expansion Downregulates CamKII...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Mouse Ataxin-2 Expansion Downregulates CamKII...