Triage May Improve Selection to Colonoscopy and Reduce the Number of Unnecessary Colonoscopies.
biomarkers
colonoscopy
colorectal cancer
early detection
feces testing
screening
triage
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
12 Sep 2020
12 Sep 2020
Historique:
received:
12
08
2020
revised:
11
09
2020
accepted:
11
09
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
17
9
2020
Statut:
epublish
Résumé
Implementation of population screening for colorectal cancer by direct colonoscopy or follow-up colonoscopy after a positive fecal blood test has challenged the overall capacity of bowel examinations. Certain countries are facing serious colonoscopy capacity constraints, which have led to waiting lists and long time latency of follow-up examinations. Various options for improvement are considered, including increased cut-off values of the fecal blood tests. Results from major clinical studies of blood-based, cancer-associated biomarkers have, however, led to focus on a Triage concept for improved selection to colonoscopy. The Triage test may include subject age, concentration of hemoglobin in a feces test and a combination of certain blood-based cancer-associated biomarkers. Recent results have indicated that Triage may reduce the requirements for colonoscopy by around 30%. Such results may be advantageous for the capacity, the healthcare budgets and in particular, the subjects, who do not need an unnecessary, unpleasant and risk-associated bowel examination.
Identifiants
pubmed: 32932734
pii: cancers12092610
doi: 10.3390/cancers12092610
pmc: PMC7563245
pii:
doi:
Types de publication
Journal Article
Langues
eng
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