L-Arginine/Nitric Oxide Pathway Is Altered in Colorectal Cancer and Can Be Modulated by Novel Derivatives from Oxicam Class of Non-Steroidal Anti-Inflammatory Drugs.
arginase (ARG)
asymmetric dimethylarginine (ADMA)
chemoprevention
dimethylamine (DMA)
dimethylarginine dimethylaminohydrolase (DDAH)
metabolic reprogramming
nitric oxide synthase (NOS)
protein methyltransferases (PRMT)
symmetric dimethylarginine (SDMA)
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
11 Sep 2020
11 Sep 2020
Historique:
received:
31
07
2020
revised:
05
09
2020
accepted:
10
09
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
17
9
2020
Statut:
epublish
Résumé
L-arginine/nitric oxide pathway metabolites are altered in colorectal cancer (CRC). We evaluated underlying changes in pathway enzymes in 55 paired tumor/tumor-adjacent samples and 20 normal mucosa using quantitative-PCR and assessed the impact of classic and novel oxicam analogues on enzyme expression and intracellular metabolite concentration (LC-MS/MS) in Caco-2, HCT116, and HT-29 cells. Compared to normal mucosa,
Identifiants
pubmed: 32932854
pii: cancers12092594
doi: 10.3390/cancers12092594
pmc: PMC7564351
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : 016/RID/2019/19
Organisme : European Regional Development Fund
ID : "WroVasc - Integrated Cardiovascular Centre"
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