Lung Microbiome Differentially Impacts Survival of Patients with Non-Small Cell Lung Cancer Depending on Tumor Stroma Phenotype.
Treg
iNOS
macrophage
microbiome
non-small cell lung cancer
prognosis
stroma
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Sep 2020
13 Sep 2020
Historique:
received:
28
07
2020
revised:
07
09
2020
accepted:
09
09
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
17
9
2020
Statut:
epublish
Résumé
The link between a lung tumor and the lung microbiome is a largely unexplored issue. To investigate the relationship between a lung microbiome and the phenotype of an inflammatory stromal infiltrate, we studied a cohort of 89 patients with non-small cell lung cancer. The microbiome was analyzed in tumor and adjacent normal tissue by 16S rRNA amplicon sequencing. Characterization of the tumor stroma was done using immunohistochemistry. We demonstrated that the bacterial load was higher in adjacent normal tissue than in a tumor (
Identifiants
pubmed: 32933105
pii: biomedicines8090349
doi: 10.3390/biomedicines8090349
pmc: PMC7554830
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Foundation for Basic Research
ID : 18-29-09069
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