Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01
epidemiology
immunology
tropical medicine
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
15
5
2021
Statut:
epublish
Résumé
Seasonal malaria chemoprevention (SMC), with sulphadoxine-pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01 This is an individually randomised, double-blind, placebo-controlled trial. 5920 children aged 5-17 months were enrolled in April 2017 in Mali and Burkina Faso. Children in group 1 received three priming doses of RTS,S/AS01 The protocol was approved by the national ethics committees of Mali and Burkina Faso and the London School of Hygiene and Tropical Medicine. The results will be presented to all stakeholders and published in open access journals. NCT03143218; Pre-results.
Identifiants
pubmed: 32933955
pii: bmjopen-2019-035433
doi: 10.1136/bmjopen-2019-035433
pmc: PMC7493088
doi:
Substances chimiques
Antimalarials
0
Malaria Vaccines
0
Banques de données
ClinicalTrials.gov
['NCT03143218']
Types de publication
Clinical Trial Protocol
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e035433Subventions
Organisme : Medical Research Council
ID : MR/P006876/1
Pays : United Kingdom
Organisme : Department of Health [UK]
Pays : International
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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