Poly(ADP-ribose) Polymerase 1 (PARP1) restrains MyoD-dependent gene expression during muscle differentiation.
Animals
Cell Differentiation
/ genetics
Cell Line
Chromatin
/ genetics
DNA Repair
/ genetics
Gene Expression Regulation
/ genetics
Histones
/ genetics
Mice
Muscle Development
/ genetics
Muscles
/ physiology
MyoD Protein
/ genetics
Poly (ADP-Ribose) Polymerase-1
/ genetics
Transcription, Genetic
/ genetics
Up-Regulation
/ genetics
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
received:
26
07
2019
accepted:
21
08
2020
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
17
12
2020
Statut:
epublish
Résumé
The myogenic factor MyoD regulates skeletal muscle differentiation by interacting with a variety of chromatin-modifying complexes. Although MyoD can induce and maintain chromatin accessibility at its target genes, its binding and trans-activation ability can be limited by some types of not fully characterized epigenetic constraints. In this work we analysed the role of PARP1 in regulating MyoD-dependent gene expression. PARP1 is a chromatin-associated enzyme, playing a well recognized role in DNA repair and that is implicated in transcriptional regulation. PARP1 affects gene expression through multiple mechanisms, often involving the Poly(ADP-ribosyl)ation of chromatin proteins. In line with PARP1 down-regulation during differentiation, we observed that PARP1 depletion boosts the up-regulation of MyoD targets, such as p57, myogenin, Mef2C and p21, while its re-expression reverts this effect. We also found that PARP1 interacts with some MyoD-binding regions and that its presence, independently of the enzymatic activity, interferes with MyoD recruitment and gene induction. We finally suggest a relationship between the binding of PARP1 and the loss of the activating histone modification H3K4me3 at MyoD-binding regions. This work highlights not only a novel player in the epigenetic control of myogenesis, but also a repressive and catalytic-independent mechanisms by which PARP1 regulates transcription.
Identifiants
pubmed: 32934320
doi: 10.1038/s41598-020-72155-8
pii: 10.1038/s41598-020-72155-8
pmc: PMC7493885
doi:
Substances chimiques
Chromatin
0
Histones
0
MyoD Protein
0
histone H3 trimethyl Lys4
0
Parp1 protein, mouse
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15086Références
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