Discovery of a Novel Inhibitor of Coronavirus 3CL Protease for the Potential Treatment of COVID-19.
Journal
bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187
Informations de publication
Date de publication:
12 Feb 2021
12 Feb 2021
Historique:
pubmed:
17
9
2020
medline:
17
9
2020
entrez:
16
9
2020
Statut:
epublish
Résumé
COVID-19 caused by the SARS-CoV-2 virus has become a global pandemic. 3CL protease is a virally encoded protein that is essential across a broad spectrum of coronaviruses with no close human analogs. The designed phosphate prodrug PF-07304814 is metabolized to PF-00835321 which is a potent inhibitor
Identifiants
pubmed: 32935104
doi: 10.1101/2020.09.12.293498
pmc: PMC7491518
pii:
doi:
Types de publication
Preprint
Langues
eng
Commentaires et corrections
Type : UpdateIn