Endothelin XVI.

Although 31 years have passed since the discovery of endothelin, that pioneering report, and the subsequent flood of influential studies elucidating its molecular and clinical details, have since paved the way for thousands of publications. They showed the promise of endothelin and the vast amount of work that remains to be done to fully unleash the potential this peptide possesses, both as a key physiological regulator and as a therapeutic target. Endothelin conferences and their proceedings have served as a host for many of these breakthrough studies, and in keeping with this fine tradition, Endothelin XVI will host novel research articles presented at the Sixteenth International Conference on Endothelin (ET-16) as its proceedings. On September 22-25, 2019, ET-16 was held at Kobe Port Oasis, Kobe, Japan, where numerous important discoveries were presented to the scientific community for the first time, many of which are compiled and published in this special issue. As the Editors of this special issue that comprises in-depth reviews, insightful editorials, and numerous original research articles discussing findings from various biomedical fields, we are extremely proud to present Endothelin XVI. We sincerely hope for the continued growth of this field for the benefit of the patients and the advancement of biomedical science.