Methylation Status of
Child
Child Development
/ physiology
Child, Preschool
DNA Methylation
Epigenesis, Genetic
/ genetics
Female
Glucagon-Like Peptide-2 Receptor
/ metabolism
Humans
Infant, Newborn
Infant, Small for Gestational Age
/ metabolism
Insulin Receptor Substrate Proteins
/ metabolism
Leptin
/ metabolism
Male
Prospective Studies
Low birth weight
infant
small for gestational age
epigenetics
methylation
DNA
insulin resistance
Journal
Journal of clinical research in pediatric endocrinology
ISSN: 1308-5735
Titre abrégé: J Clin Res Pediatr Endocrinol
Pays: Turkey
ID NLM: 101519456
Informations de publication
Date de publication:
02 06 2021
02 06 2021
Historique:
entrez:
16
9
2020
pubmed:
17
9
2020
medline:
12
1
2022
Statut:
ppublish
Résumé
In small for gestational age (SGA) children, catch-up growth could be influenced by methylation of several genes involved in metabolism. Epigenetics may influence the development of metabolic diseases in adulthood. To compare the methylation of leptin ( Observational prospective study of SGA children. Demographical and clinical variables were collected from clinical records and parents’ questionnaire. Methylation status of Forty-eight SGA patients were included. Twenty-six (54.2%) had catch-up growth phenotype and 22 (45.8%) did not. The median age was 5.2 years [RIC 4.1-6.8] without difference between groups (p=0.306). The catch-up group had increased appetite (42.3% vs 9.1%, p=0.008), family history of dyslipidemia (42.3% vs 27.3%) and diabetes (34.6% vs 22.7%) compared to non-catch-up group. Catch-up patients had significantly larger waist circumference compared to non-catch-up group (median 55 cm [RIC 52-58] versus median 49.5 cm [RIC46-52]; p<0.001). There is no association between
Identifiants
pubmed: 32936762
doi: 10.4274/jcrpe.galenos.2020.2020.0070
pmc: PMC8186343
doi:
Substances chimiques
GLP2R protein, human
0
Glucagon-Like Peptide-2 Receptor
0
IRS2 protein, human
0
Insulin Receptor Substrate Proteins
0
LEP protein, human
0
Leptin
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
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