The Pathopharmacological Interplay between Vanadium and Iron in Parkinson's Disease Models.
Animals
Catecholamines
/ metabolism
Disease Models, Animal
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ metabolism
Iron
/ metabolism
Iron Chelating Agents
/ pharmacology
Metals, Heavy
/ toxicity
Oxidative Stress
/ drug effects
Parkinson Disease
/ drug therapy
Protein Serine-Threonine Kinases
/ metabolism
Reactive Oxygen Species
/ metabolism
Vanadium
/ metabolism
Parkinson’s
RONS
iron
mitochondria
motor activity
oxidative stress
vanadium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Sep 2020
14 Sep 2020
Historique:
received:
13
08
2020
revised:
05
09
2020
accepted:
08
09
2020
entrez:
17
9
2020
pubmed:
18
9
2020
medline:
25
2
2021
Statut:
epublish
Résumé
Parkinson's disease (PD) pathology is characterised by distinct types of cellular defects, notably associated with oxidative damage and mitochondria dysfunction, leading to the selective loss of dopaminergic neurons in the brain's substantia nigra pars compacta (SNpc). Exposure to some environmental toxicants and heavy metals has been associated with PD pathogenesis. Raised iron levels have also been consistently observed in the nigrostriatal pathway of PD cases. This study explored, for the first time, the effects of an exogenous environmental heavy metal (vanadium) and its interaction with iron, focusing on the subtoxic effects of these metals on PD-like oxidative stress phenotypes in Catecholaminergic a-differentiated (CAD) cells and PTEN-induced kinase 1 (PINK-1)
Identifiants
pubmed: 32937783
pii: ijms21186719
doi: 10.3390/ijms21186719
pmc: PMC7554808
pii:
doi:
Substances chimiques
Catecholamines
0
Drosophila Proteins
0
Iron Chelating Agents
0
Metals, Heavy
0
Reactive Oxygen Species
0
Vanadium
00J9J9XKDE
Iron
E1UOL152H7
PINK1 protein, Drosophila
EC 2.7.11.1
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : undefined <span style="color:gray;font-size:10px;">undefined</span>
ID : chazot
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