The Role of PPARγ Ligands in Breast Cancer: From Basic Research to Clinical Studies.
15-deoxy-D12,14-prostaglandin J2
PUFA
natural PPARγ agonists
nonsteroidal anti-inflammatory drugs
omega-3 polyunsaturated fatty acids
peroxisome proliferator-activated receptor gamma
selective PPARγ modulators
synthetic PPARγ agonists
thiazolidinediones
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
14 Sep 2020
14 Sep 2020
Historique:
received:
07
08
2020
revised:
11
09
2020
accepted:
12
09
2020
entrez:
17
9
2020
pubmed:
18
9
2020
medline:
18
9
2020
Statut:
epublish
Résumé
Peroxisome proliferator-activated receptor gamma (PPARγ), belonging to the nuclear receptor superfamily, is a ligand-dependent transcription factor involved in a variety of pathophysiological conditions such as inflammation, metabolic disorders, cardiovascular disease, and cancers. In this latter context, PPARγ is expressed in many tumors including breast cancer, and its function upon binding of ligands has been linked to the tumor development, progression, and metastasis. Over the last decade, much research has focused on the potential of natural agonists for PPARγ including fatty acids and prostanoids that act as weak ligands compared to the strong and synthetic PPARγ agonists such as thiazolidinedione drugs. Both natural and synthetic compounds have been implicated in the negative regulation of breast cancer growth and progression. The aim of the present review is to summarize the role of PPARγ activation in breast cancer focusing on the underlying cellular and molecular mechanisms involved in the regulation of cell proliferation, cell cycle, and cell death, in the modulation of motility and invasion as well as in the cross-talk with other different signaling pathways. Besides, we also provide an overview of the in vivo breast cancer models and clinical studies. The therapeutic effects of natural and synthetic PPARγ ligands, as antineoplastic agents, represent a fascinating and clinically a potential translatable area of research with regards to the battle against cancer.
Identifiants
pubmed: 32937951
pii: cancers12092623
doi: 10.3390/cancers12092623
pmc: PMC7564201
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : BANDO PRIN 2017
ID : #2017WNKSLR_005
Organisme : BANDO PRIN 2017
ID : #2017EKMFTN
Organisme : Fondazione AIRC
ID : IG #21414
Organisme : BANDO PRIN 2015
ID : #2015B7M39T
Références
Eur J Biochem. 2004 Jan;271(2):386-97
pubmed: 14717706
J Nutr Biochem. 2013 Jan;24(1):388-95
pubmed: 23026490
Annu Rev Food Sci Technol. 2018 Mar 25;9:345-381
pubmed: 29350557
Nat Rev Dis Primers. 2019 Sep 23;5(1):66
pubmed: 31548545
Histopathology. 2005 Jan;46(1):37-42
pubmed: 15656884
Eur J Clin Nutr. 2017 Jun;71(6):762-765
pubmed: 28145413
Cancer Prev Res (Phila). 2015 Oct;8(10):922-31
pubmed: 26276744
Nutr Metab (Lond). 2013 Apr 23;10(1):36
pubmed: 23618064
Endocr Relat Cancer. 2008 Jun;15(2):545-57
pubmed: 18509005
J Clin Lipidol. 2015 Nov-Dec;9(6):770-777
pubmed: 26687697
Anticancer Agents Med Chem. 2012 Nov;12(9):1025-44
pubmed: 22583414
Int J Oncol. 2018 Jun;52(6):1991-2000
pubmed: 29620161
Oncotarget. 2016 Oct 4;7(40):65109-65124
pubmed: 27556298
Ann Pharmacother. 2013 Jun;47(6):877-85
pubmed: 23632280
Nat Rev Cancer. 2009 Mar;9(3):153-66
pubmed: 19238148
Cells. 2019 Jul 03;8(7):
pubmed: 31277291
Cancer Treat Rev. 2014 Jul;40(6):739-49
pubmed: 24480385
Life Sci. 2008 Mar 12;82(11-12):615-22
pubmed: 18262572
PPAR Res. 2008;2008:102737
pubmed: 18584037
Lipids Health Dis. 2014 Jun 11;13:96
pubmed: 24916956
Nutr Res Rev. 2016 Dec;29(2):281-294
pubmed: 27866493
Biochem Biophys Res Commun. 2003 Jun 6;305(3):557-65
pubmed: 12763030
Mol Pharmacol. 2012 Jun;81(6):788-99
pubmed: 22391103
Cancer. 2012 Nov 1;118(21):5403-13
pubmed: 22570147
World J Gastrointest Oncol. 2010 Mar 15;2(3):159-64
pubmed: 21160824
Curr Pharmacol Rep. 2015 Oct;1(5):283-294
pubmed: 26457243
Carcinogenesis. 2005 Jan;26(1):81-92
pubmed: 15485993
PPAR Res. 2007;2007:53843
pubmed: 17389765
Cancer Res. 2003 Sep 15;63(18):5926-39
pubmed: 14522919
J Cancer Res Clin Oncol. 2009 Nov;135(11):1551-9
pubmed: 19495794
Mol Cancer Res. 2007 Jun;5(6):523-30
pubmed: 17579114
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2340-5
pubmed: 15701701
Nutr Cancer. 2020 Aug 19;:1-11
pubmed: 32812824
Carcinogenesis. 2003 Nov;24(11):1717-22
pubmed: 12949056
J Breast Cancer. 2012 Sep;15(3):265-72
pubmed: 23091538
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Mol Cell Biol. 1998 Jun;18(6):3483-94
pubmed: 9584188
Biochem Pharmacol. 2014 Nov 1;92(1):73-89
pubmed: 25083916
Mol Endocrinol. 1995 Jul;9(7):794-804
pubmed: 7476963
Breast Cancer Res Treat. 2017 Jan;161(2):299-310
pubmed: 27913933
Mol Cell Biol. 2001 May;21(9):3057-70
pubmed: 11287611
Menopause. 2008 Nov-Dec;15(6):1120-31
pubmed: 18724264
Biochim Biophys Acta. 2007 Aug;1771(8):926-35
pubmed: 17433773
Prog Biophys Mol Biol. 2020 Mar;151:40-53
pubmed: 31761352
Cancer Res. 2008 Apr 15;68(8):2912-9
pubmed: 18413760
PPAR Res. 2007;2007:32696
pubmed: 17389769
J Nutr Biochem. 2014 Feb;25(2):104-10
pubmed: 24290517
Int J Nutr. 2017;1(4):31-49
pubmed: 29683134
PPAR Res. 2008;2008:358052
pubmed: 18769551
Mini Rev Med Chem. 2016;16(8):596-604
pubmed: 26156544
J Cell Sci. 2001 Nov;114(Pt 22):4117-26
pubmed: 11739643
Cancer Epidemiol Biomarkers Prev. 2017 Apr;26(4):444-457
pubmed: 28223433
Front Endocrinol (Lausanne). 2017 Feb 22;8:31
pubmed: 28275367
Exp Mol Pathol. 2011 Dec;91(3):768-74
pubmed: 21930124
Mol Nutr Food Res. 2013 Feb;57(2):320-7
pubmed: 23213007
Semin Cancer Biol. 2015 Dec;35 Suppl:S25-S54
pubmed: 25892662
Kidney Int. 2001 Jul;60(1):14-30
pubmed: 11422732
Obes Res. 2002 Jun;10(6):518-25
pubmed: 12055328
Endocr Relat Cancer. 2017 Apr;24(4):181-195
pubmed: 28213567
Am J Clin Nutr. 2008 Apr;87(4):939-48
pubmed: 18400717
Nature. 2015 Sep 17;525(7569):380-3
pubmed: 26331539
Breast Cancer Res Treat. 2002 Jul;74(2):155-65
pubmed: 12186376
PLoS One. 2010 Apr 22;5(4):e10296
pubmed: 20421971
Breast Cancer Res Treat. 2015 Apr;150(3):511-22
pubmed: 25794775
Biochim Biophys Acta. 2002 Apr 15;1581(3):89-99
pubmed: 12020636
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6
pubmed: 10339548
Nat Rev Cancer. 2005 Aug;5(8):591-602
pubmed: 16056258
Cells. 2020 Jan 10;9(1):
pubmed: 31936729
Front Nutr. 2019 Sep 06;6:144
pubmed: 31555658
Int J Mol Med. 2003 Jun;11(6):733-6
pubmed: 12736714
Bioorg Chem. 2018 Apr;77:548-567
pubmed: 29475164
Elife. 2018 Dec 21;7:
pubmed: 30575522
Clin Cancer Res. 2007 Jan 1;13(1):246-52
pubmed: 17200362
Mol Nutr Food Res. 2015 Sep;59(9):1780-90
pubmed: 26081224
PPAR Res. 2018 Oct 21;2018:2010675
pubmed: 30420872
BMJ Open Diabetes Res Care. 2017 Nov 30;5(1):e000435
pubmed: 29299328
Annu Rev Biochem. 2008;77:289-312
pubmed: 18518822
J Nutr Biochem. 2012 Nov;23(11):1440-8
pubmed: 22305406
J Clin Oncol. 2015 Jun 10;33(17):1910-7
pubmed: 25940724
Am J Pathol. 2009 Sep;175(3):1270-80
pubmed: 19644018
Int J Mol Sci. 2018 Jun 12;19(6):
pubmed: 29895749
Breast Cancer Res Treat. 2003 Jun;79(3):391-7
pubmed: 12846423
Oncol Lett. 2017 Jan;13(1):243-249
pubmed: 28123548
Biochem Biophys Res Commun. 1997 Apr 28;233(3):756-9
pubmed: 9168928
Biochim Biophys Acta. 2011 Aug;1812(8):1007-22
pubmed: 21382489
Autophagy. 2018;14(2):207-215
pubmed: 28933638
Annu Rev Med. 2002;53:409-35
pubmed: 11818483
PPAR Res. 2012;2012:617063
pubmed: 22919366
Int J Mol Sci. 2016 Jan 19;17(1):
pubmed: 26797605
FASEB J. 2009 Jun;23(6):1625-37
pubmed: 19141537
Nat Struct Mol Biol. 2008 Sep;15(9):924-31
pubmed: 19172745
Cancer Biol Med. 2017 Nov;14(4):348-362
pubmed: 29372101
J Biol Chem. 1997 Feb 7;272(6):3406-10
pubmed: 9013583
Front Neurosci. 2019 Aug 28;13:907
pubmed: 31555078
Am J Pathol. 2011 Aug;179(2):1030-40
pubmed: 21704006
Biochim Biophys Acta. 2015 Nov;1850(11):2185-95
pubmed: 26272430
Sci Rep. 2014 Oct 21;4:6697
pubmed: 25331725
Oncogene. 2011 Sep 29;30(39):4129-40
pubmed: 21499302
PPAR Res. 2015;2015:816856
pubmed: 26435709
FEBS Lett. 1998 Oct 30;438(1-2):55-60
pubmed: 9821958
JAMA. 2019 Jan 22;321(3):288-300
pubmed: 30667505
Carcinogenesis. 1999 Oct;20(10):1905-11
pubmed: 10506103
Nutr Res. 2012 Jan;32(1):1-7
pubmed: 22260857
Breast Cancer Res Treat. 2009 Feb;113(3):423-34
pubmed: 18293083
J Biol Chem. 2002 May 17;277(20):17830-5
pubmed: 11884400
Cell Cycle. 2011 Jul 15;10(14):2344-54
pubmed: 21654191
Nutr Cancer. 2011;63(6):930-9
pubmed: 21745038
PLoS One. 2014 Aug 13;9(8):e104592
pubmed: 25119466
Mol Cell Endocrinol. 2002 Aug 30;194(1-2):123-33
pubmed: 12242035
Cells. 2020 Feb 03;9(2):
pubmed: 32028565
Cancer Res. 2000 Mar 15;60(6):1604-8
pubmed: 10749129
Nucl Recept Signal. 2015 Oct 05;13:e004
pubmed: 26445566
Cancer Chemother Pharmacol. 2013 Jan;71(1):63-72
pubmed: 23053261
Int J Biochem Cell Biol. 2009 Nov;41(11):2334-42
pubmed: 19563910
Diabetes Metab Syndr. 2015 Jan-Mar;9(1):46-50
pubmed: 25450819
PLoS One. 2015 Aug 04;10(8):e0134996
pubmed: 26241474
Cell Cycle. 2018;17(15):1871-1885
pubmed: 30078354
BMC Med. 2015 Aug 17;13:195
pubmed: 26278220
Arch Immunol Ther Exp (Warsz). 2008 Sep-Oct;56(5):331-45
pubmed: 18836859
Lipids Health Dis. 2016 Sep 29;15(1):168
pubmed: 27687127
Cancer Res. 2009 Nov 15;69(22):8636-44
pubmed: 19887620
Expert Opin Drug Saf. 2009 Jan;8(1):15-32
pubmed: 19236215
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
BMB Rep. 2020 Apr;53(4):212-217
pubmed: 31964465
J Cell Physiol. 2014 Nov;229(11):1595-606
pubmed: 24604522
Cancer Res. 2012 Aug 1;72(15):3795-806
pubmed: 22651929
Mol Endocrinol. 2006 Dec;20(12):3083-92
pubmed: 16887883
Diabetes Metab Res Rev. 2011 May;27(4):392-401
pubmed: 21328517
Nutr Res. 2011 Jul;31(7):503-8
pubmed: 21840466
Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8806-11
pubmed: 9671760
Bone. 2006 Jan;38(1):74-84
pubmed: 16137931
J Breast Cancer. 2018 Mar;21(1):28-36
pubmed: 29628981
J Pathol. 2012 Jan;226(2):352-64
pubmed: 21990031
Clin Cancer Res. 2005 Sep 1;11(17):6139-47
pubmed: 16144913
Biochem Biophys Res Commun. 2008 Dec 5;377(1):242-7
pubmed: 18835379
Biochem Biophys Res Commun. 2001 Sep 7;286(5):916-22
pubmed: 11527386
Cancer Lett. 2016 Jan 28;370(2):250-9
pubmed: 26545738
Free Radic Biol Med. 2008 Apr 1;44(7):1483-91
pubmed: 18267129
J Cell Physiol. 2013 Jun;228(6):1314-22
pubmed: 23168911
PPAR Res. 2016;2016:6042162
pubmed: 27148361
Cancer Prev Res (Phila). 2015 Oct;8(10):912-21
pubmed: 26438592
Domest Anim Endocrinol. 2002 Mar;22(1):1-23
pubmed: 11900961
Diabetes Metab Res Rev. 2002 Mar-Apr;18 Suppl 2:S10-5
pubmed: 11921433
Int J Mol Sci. 2019 Oct 11;20(20):
pubmed: 31614433
Breast Cancer Res Treat. 2003 May;79(1):63-74
pubmed: 12779083
Breast Cancer Res Treat. 2009 Nov;118(1):213-28
pubmed: 18953692
Breast Cancer Res. 2015 May 04;17:62
pubmed: 25936773
Int J Mol Sci. 2020 Mar 26;21(7):
pubmed: 32224850
Eur J Pharmacol. 2016 Aug 15;785:44-49
pubmed: 26632493
Mol Cell. 2001 Oct;8(4):737-47
pubmed: 11684010
Breast Cancer Res Treat. 1997 Nov-Dec;46(2-3):225-37
pubmed: 9478277
Am J Epidemiol. 2007 Nov 15;166(10):1116-25
pubmed: 17823383