Fortified Coiled Coils: Enhancing Mechanical Stability with Lactam or Metal Staples.
coiled coil
lactam
metal coordination
peptide stapling
single-molecule force spectroscopy
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
04 01 2021
04 01 2021
Historique:
received:
14
05
2020
pubmed:
18
9
2020
medline:
18
9
2020
entrez:
17
9
2020
Statut:
ppublish
Résumé
Coiled coils (CCs) are powerful supramolecular building blocks for biomimetic materials, increasingly used for their mechanical properties. Here, we introduce helix-inducing macrocyclic constraints, so-called staples, to tune thermodynamic and mechanical stability of CCs. We show that thermodynamic stabilization of CCs against helix uncoiling primarily depends on the number of staples, whereas staple positioning controls CC mechanical stability. Inserting a covalent lactam staple at one key force application point significantly increases the barrier to force-induced CC dissociation and reduces structural deformity. A reversible His-Ni
Identifiants
pubmed: 32940968
doi: 10.1002/anie.202006971
pmc: PMC7821110
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-236Informations de copyright
© 2020 The Authors. Published by Wiley-VCH GmbH.
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