Plasmodium vivax Strains Use Alternative Pathways for Invasion.
Plasmodium vivax
DARC
TfR1
parasite invasion
receptor blockade
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
28
07
2020
accepted:
16
09
2020
pubmed:
18
9
2020
medline:
12
2
2022
entrez:
17
9
2020
Statut:
ppublish
Résumé
Plasmodium vivax has 2 invasion ligand/host receptor pathways (P. vivax Duffy-binding protein/Duffy antigen receptor for chemokines [DARC] and P. vivax reticulocyte binding protein 2b/transferrin receptor [TfR1]) that are promising targets for therapeutic intervention. We optimized invasion assays with isogenic cultured reticulocytes. Using a receptor blockade approach with multiple P. vivax isolates, we found that all strains utilized both DARC and TfR1, but with significant variation in receptor usage. This suggests that P. vivax, like Plasmodium falciparum, uses alternative invasion pathways, with implications for pathogenesis and vaccine development.
Identifiants
pubmed: 32941614
pii: 5907984
doi: 10.1093/infdis/jiaa592
pmc: PMC8161644
doi:
Substances chimiques
ACKR1 protein, human
0
Antigens, CD
0
CD71 antigen
0
Duffy Blood-Group System
0
Receptors, Cell Surface
0
Receptors, Transferrin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1817-1821Subventions
Organisme : NIAID NIH HHS
ID : U19 AI089688
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140751
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
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