A Cellular Mechanism to Detect and Alleviate Reductive Stress.

Antioxidants / metabolism Carrier Proteins / genetics Cell Differentiation HEK293 Cells Homeostasis Humans Kelch-Like ECH-Associated Protein 1 / metabolism Mitochondria Muscle Development / physiology Myoblasts / metabolism NF-E2-Related Factor 2 / metabolism Oxidative Stress / physiology Reactive Oxygen Species / metabolism Signal Transduction Ubiquitin-Protein Ligases / metabolism Ubiquitination
FEM1B FNIP1 KEAP1 mitochondria oxidative stress proteasome reactive oxygen reductive stress ubiquitin

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
01 10 2020
Historique:
received: 18 12 2019
revised: 28 05 2020
accepted: 18 08 2020
pubmed: 18 9 2020
medline: 18 5 2021
entrez: 17 9 2020
Statut: ppublish

Résumé

Metazoan organisms rely on conserved stress response pathways to alleviate adverse conditions and preserve cellular integrity. Stress responses are particularly important in stem cells that provide lifetime support for tissue formation and repair, but how these protective systems are integrated into developmental programs is poorly understood. Here we used myoblast differentiation to identify the E3 ligase CUL2

Identifiants

DOI: 10.1016/j.cell.2020.08.034 PMID: 32941802
pubmed: 32941802
pii: S0092-8674(20)31076-X
doi: 10.1016/j.cell.2020.08.034
pii:
doi:

Substances chimiques

Antioxidants 0
Carrier Proteins 0
FNIP1 protein, human 0
Kelch-Like ECH-Associated Protein 1 0
NF-E2-Related Factor 2 0
Reactive Oxygen Species 0
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

46-61.e21

Subventions

Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIH HHS
ID : S10 OD020062
Pays : United States
Organisme : NIH HHS
ID : S10 OD018174
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interest M.R. is a co-founder and consultant to Nurix, a publicly traded company in the ubiquitin space. D.K.N. is a co-founder, shareholder, and adviser of Frontier Medicines.

Auteurs

Andrew G Manford (AG)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA.

Fernando Rodríguez-Pérez (F)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA.

Karen Y Shih (KY)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA.

Zhuo Shi (Z)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA.

Charles A Berdan (CA)

Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA.

Mangyu Choe (M)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Center for Computational Biology, University of California at Berkeley, Berkeley CA 94720, USA.

Denis V Titov (DV)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Center for Computational Biology, University of California at Berkeley, Berkeley CA 94720, USA.

Daniel K Nomura (DK)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Nutritional Science and Toxicology, University of California at Berkeley, Berkeley CA 94720, USA; Department of Chemistry, University of California at Berkeley, CA 94720, USA.

Michael Rape (M)

Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley CA 94720, USA; Howard Hughes Medical Institute, University of California at Berkeley, Berkeley CA 94720, USA; California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, CA 94720, USA. Electronic address: mrape@berkeley.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Protéine-1 de type kelch associée à ECH › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Développement musculaire › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Cellules › Cellules souches › Myoblastes › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › A Cellular Mechanism to Detect and Alleviate...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Ubiquitination › A Cellular Mechanism to Detect and Alleviate...