Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
received:
03
01
2020
accepted:
17
07
2020
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
2
12
2020
Statut:
ppublish
Résumé
Although mechanisms of embryonic development are similar between mice and humans, the time scale is generally slower in humans. To investigate these interspecies differences in development, we recapitulate murine and human segmentation clocks that display 2- to 3-hour and 5- to 6-hour oscillation periods, respectively. Our interspecies genome-swapping analyses indicate that the period difference is not due to sequence differences in the
Identifiants
pubmed: 32943519
pii: 369/6510/1450
doi: 10.1126/science.aba7668
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
HES7 protein, human
0
Hes7 protein, mouse
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1450-1455Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.