Systemic complement activation is associated with respiratory failure in COVID-19 hospitalized patients.
Aged
Betacoronavirus
/ immunology
Biomarkers
/ blood
COVID-19
Case-Control Studies
Complement Activation
Coronavirus Infections
/ blood
Female
Host-Pathogen Interactions
/ immunology
Humans
Male
Mannose-Binding Lectin
/ blood
Middle Aged
Pandemics
Pneumonia, Viral
/ blood
Respiratory Insufficiency
/ immunology
SARS-CoV-2
Viral Load
COVID-19
SARS-CoV-2
complement system
respiratory failure
sC5b-9
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
06 10 2020
06 10 2020
Historique:
pubmed:
19
9
2020
medline:
21
10
2020
entrez:
18
9
2020
Statut:
ppublish
Résumé
Respiratory failure in the acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is hypothesized to be driven by an overreacting innate immune response, where the complement system is a key player. In this prospective cohort study of 39 hospitalized coronavirus disease COVID-19 patients, we describe systemic complement activation and its association with development of respiratory failure. Clinical data and biological samples were obtained at admission, days 3 to 5, and days 7 to 10. Respiratory failure was defined as PO
Identifiants
pubmed: 32943538
pii: 2010540117
doi: 10.1073/pnas.2010540117
pmc: PMC7547220
doi:
Substances chimiques
Biomarkers
0
Mannose-Binding Lectin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25018-25025Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Competing interest statement: T.E.M. is a member of the Scientific Advisory Board for Ra Pharmaceutical producing complement inhibitors. All other authors declare no competing interests.
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