Acute exacerbations of COPD and risk of lung cancer in COPD patients with and without a history of asthma.
COPD
asthma
exacerbations
lung cancer
Journal
European clinical respiratory journal
ISSN: 2001-8525
Titre abrégé: Eur Clin Respir J
Pays: United States
ID NLM: 101662134
Informations de publication
Date de publication:
07 Aug 2020
07 Aug 2020
Historique:
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
19
9
2020
Statut:
epublish
Résumé
There is limited knowledge on the effect of acute exacerbations in chronic obstructive pulmonary disease (AECOPD) on lung cancer risk in COPD patients with and without a history of asthma. This study aims to examine whether AECOPD is associated with risk of lung cancer, and whether the effect depends on a history of asthma. In the GenKOLS study of 2003-2005, 852 subjects with COPD performed spirometry, and filled out questionnaires on smoking habits, symptoms and disease history. These data were linked to lung cancer data from the Cancer Registry of Norway through 2013. AECOPD, measured at baseline was the main predictor. To quantify differences in lung cancer risk, we performed Cox-proportional hazards regression. We adjusted for sex, age, smoking variables, body mass index, and lung function. During follow-up, 8.8% of the subjects with, and 5.9% of the subjects without exacerbations were diagnosed with lung cancer. Cox regression showed a significant increased risk of lung cancer with one or more exacerbations in COPD patients without a history of asthma, HRR = 2.77 (95% CI 1.39-5.52). We found a significant interaction between a history of asthma and AECOPD on lung cancer. AECOPD is associated with an increased risk of lung cancer in COPD patients without a history of asthma.
Identifiants
pubmed: 32944202
doi: 10.1080/20018525.2020.1799540
pii: 1799540
pmc: PMC7480432
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1799540Informations de copyright
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the authors.
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