The effects of varicocelectomy on the DNA fragmentation index and other sperm parameters: a meta-analysis.
DNA fragmentation
Sperm analysis
Varicocele
Varicocelectomy
Journal
Basic and clinical andrology
ISSN: 2051-4190
Titre abrégé: Basic Clin Androl
Pays: England
ID NLM: 101640161
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
06
2020
accepted:
17
08
2020
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
19
9
2020
Statut:
epublish
Résumé
Varicocele is one of the most common causes of reversible male infertility, and 15% of the varicocele patients with normal semen analysis are diagnosed as infertile. According to the current guidelines, varicocelectomy is indicated based on abnormal sperm parameters and not abnormal DNA fragmentation index (DFI) values. Thus, in this study, we performed a meta-analysis of the effects of varicocelectomy on the DFI and other conventional sperm parameters, and determined whether DFI could be used to indicate varicocelectomy for varicocele patients. Through an electronic search of the PubMed, Scopus, EBSCO, and Cochrane databases, we included 7 prospective studies including a total of 289 patients in this meta-analysis. The results showed that varicocelectomy significantly reduced DNA fragmentation (mean difference: - 6.86; 95% confidence interval [CI]: - 10.04, - 3.69; Varicocelectomy reduced DNA fragmentation and improved sperm concentration, progressive motility, and morphology. Additionally, the analysis showed that an abnormal DFI measurement should be considered as an indication for varicocelectomy.
Sections du résumé
BACKGROUND
BACKGROUND
Varicocele is one of the most common causes of reversible male infertility, and 15% of the varicocele patients with normal semen analysis are diagnosed as infertile. According to the current guidelines, varicocelectomy is indicated based on abnormal sperm parameters and not abnormal DNA fragmentation index (DFI) values. Thus, in this study, we performed a meta-analysis of the effects of varicocelectomy on the DFI and other conventional sperm parameters, and determined whether DFI could be used to indicate varicocelectomy for varicocele patients.
RESULTS
RESULTS
Through an electronic search of the PubMed, Scopus, EBSCO, and Cochrane databases, we included 7 prospective studies including a total of 289 patients in this meta-analysis. The results showed that varicocelectomy significantly reduced DNA fragmentation (mean difference: - 6.86; 95% confidence interval [CI]: - 10.04, - 3.69;
CONCLUSION
CONCLUSIONS
Varicocelectomy reduced DNA fragmentation and improved sperm concentration, progressive motility, and morphology. Additionally, the analysis showed that an abnormal DFI measurement should be considered as an indication for varicocelectomy.
Identifiants
pubmed: 32944248
doi: 10.1186/s12610-020-00112-6
pii: 112
pmc: PMC7488296
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
15Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare that they have no competing interests.
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