Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress.
Arginine methylation
LLPS
PRMT1
SASP
cisplatin
mass spectrometry-based proteomics
phosphorylation
stress granules
Journal
Molecular & cellular oncology
ISSN: 2372-3556
Titre abrégé: Mol Cell Oncol
Pays: United States
ID NLM: 101642411
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
18
9
2020
pubmed:
19
9
2020
medline:
19
9
2020
Statut:
epublish
Résumé
We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which - we speculate - may promote their phase separation and stress granules formation.
Identifiants
pubmed: 32944613
doi: 10.1080/23723556.2020.1743808
pii: 1743808
pmc: PMC7469493
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1743808Informations de copyright
© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
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