Canine mammary tumours: Size matters-a progression from low to highly malignant subtypes.
carcinoma
dog
malignant transformation
mammary tumour
oncology
Journal
Veterinary and comparative oncology
ISSN: 1476-5829
Titre abrégé: Vet Comp Oncol
Pays: England
ID NLM: 101185242
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
revised:
18
08
2020
received:
27
02
2020
accepted:
28
08
2020
pubmed:
19
9
2020
medline:
27
1
2022
entrez:
18
9
2020
Statut:
ppublish
Résumé
The purpose of this study was to evaluate a possible association between mammary tumour size and increasing degree of malignancy. Data of 625 dogs with a total of 1459 mammary tumours were analysed retrospectively. 80.3% dogs were intact, mean age at diagnosis was 9.7 ± 2.5 years, 75.8% were pure breed dogs. Median body weight was 20.0 kg. Malignant tumours (n = 580) were significantly larger than their benign counterparts (1.94 cm vs 0.90 cm in mean, respectively; P ≤ .0001), resulting in a positive correlation between increasing tumour size and a change from benign to malignant (P ≤ .0001; r
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
707-713Informations de copyright
© 2020 John Wiley & Sons Ltd.
Références
Vascellari M, Capello K, Carminato A, Zanardello C, Baioni E, Mutinelli F. Incidence of mammary tumors in the canine population living in the Veneto region (northeastern Italy): risk factors and similarities to human breast cancer. Prev Vet Med. 2016;126:183-189.
Dorn CR, Taylor DO, Schneider R, Hibbard HH, Klauber MR. Survey of animal neoplasms in alameda and contra costa counties, California. II. Cancer morbidity in dogs and cats from Alameda County. J Natl Cancer Inst. 1968;40(2):307-318.
Benjamin SA, Lee AC, Saunders WJ. Classification and behavior of canine mammary epithelial neoplasms based on life-span observations in beagles. Vet Pathol. 1999;36(5):423-436.
Stratmann N, Failing K, Richter A, Wehrend A. Mammary tumor recurrence in bitches after regional mastectomy. Vet Surg. 2008;37(1):82-86.
Stratmann NF, Wehrend K. Investigations on localisation and dignity of mammary tumours in bitches with multiple mammary neoplasias. Tierärztliche Praxis. 2006;34 (1):23-28.
Gunnes G, Borge KS, Lingaas F. A statistical assessment of the biological relationship between simultaneous canine mammary tumours. Vet Comp Oncol. 2017;15(2):355-365.
Salas Y, Marquez A, Diaz D, Romero L. Epidemiological study of mammary tumors in female dogs diagnosed during the period 2002-2012: a growing animal health problem. PLoS One. 2015;10(5):e0127381.
Itoh T, Uchida K, Ishikawa K, et al. Clinicopathological survey of 101 canine mammary gland tumors: differences between small-breed dogs and others. J Vet Med Sci. 2005;67(3):345-347.
Schmidt JM, Kessler M, des Hundes M. In: Kessler M, ed. Kleintieronkologie. 3ed ed. Stuttgart: Enke Verlag; 2013:241-252.
Clemente M, Perez-Alenza MD, Illera JC, Pena L. Histological, immunohistological, and ultrastructural description of vasculogenic mimicry in canine mammary cancer. Vet Pathol. 2010;47(2):265-274.
Pena L, De Andres PJ, Clemente M, Cuesta P, Perez-Alenza MD. Prognostic value of histological grading in noninflammatory canine mammary carcinomas in a prospective study with two-year follow-up: relationship with clinical and histological characteristics. Vet Pathol. 2013;50(1):94-105.
Goldschmidt M, Pena L, Rasotto R, Zappulli V. Classification and grading of canine mammary tumors. Vet Pathol. 2011;48(1):117-131.
Misdorp W ER, Hellmen E, et al. Histologic classification of mammary tumors of the dog and the cat. Armed Force Institute of Pathology and World Health Organization. 1999; 7(59).
Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991;19(5):403-410.
Santos M, Correia-Gomes C, Marcos R, et al. Value of the Nottingham histological grading parameters and Nottingham prognostic index in canine mammary carcinoma. Anticancer Res. 2015;35(7):4219-4227.
Karayannopoulou M, Kaldrymidou E, Constantinidis TC, Dessiris A. Histological grading and prognosis in dogs with mammary carcinomas: application of a human grading method. J Comp Pathol. 2005;133(4):246-252.
Rasotto R, Berlato D, Goldschmidt MH, Zappulli V. Prognostic significance of canine mammary tumor histologic subtypes: an observational cohort study of 229 cases. Vet Pathol. 2017;54(4):571-578.
Hartmann LC, Degnim AC, Santen RJ, Dupont WD, Ghosh K. Atypical hyperplasia of the breast-risk assessment and management options. N Engl J Med. 2015;372(1):78-89.
Lakhani SR. The transition from hyperplasia to invasive carcinoma of the breast. J Pathol. 1999;187(3):272-278.
Sinn HP, Elsawaf Z, Helmchen B, Aulmann S. Early breast cancer precursor lesions: lessons learned from molecular and clinical studies. Breast Care (Basel). 2010;5(4):218-226.
Renshaw AA, Gould EW. Long term clinical follow-up of atypical ductal hyperplasia and lobular carcinoma in situ in breast core needle biopsies. Pathology. 2016;48(1):25-29.
Gilbertson SR, Kurzman ID, Zachrau RE, Hurvitz AI, Black MM. Canine mammary epithelial neoplasms: biologic implications of morphologic characteristics assessed in 232 dogs. Vet Pathol. 1983;20(2):127-142.
Antuofermo E, Miller MA, Pirino S, Xie J, Badve S, Mohammed SI. Spontaneous mammary intraepithelial lesions in dogs-a model of breast cancer. Cancer Epidemiol Biomarkers Prev. 2007;16(11):2247-2256.
Ferreira E, Gobbi H, Saraiva BS, Cassali GD. Histological and immunohistochemical identification of atypical ductal mammary hyperplasia as a preneoplastic marker in dogs. Vet Pathol. 2012;49(2):322-329.
Sorenmo KU, Kristiansen VM, Cofone MA, et al. Canine mammary gland tumours; a histological continuum from benign to malignant; clinical and histopathological evidence. Vet Comp Oncol. 2009;7(3):162-172.
Philibert JC, Snyder PW, Glickman N, Glickman LT, Knapp DW, Waters DJ. Influence of host factors on survival in dogs with malignant mammary gland tumors. J Vet Intern Med. 2003;17(1):102-106.
Chang SC, Chang CC, Chang TJ, Wong ML. Prognostic factors associated with survival two years after surgery in dogs with malignant mammary tumors: 79 cases (1998-2002). J Am Vet Med Assoc. 2005;227(10):1625-1629.
Ferreira E, Bertagnolli AC, Cavalcanti MF, Schmitt FC, Cassali GD. The relationship between tumour size and expression of prognostic markers in benign and malignant canine mammary tumours. Vet Comp Oncol. 2009;7(4):230-235.
Misdorp W, Hart AA. Prognostic factors in canine mammary cancer. J Natl Cancer Inst. 1976;56(4):779-786.
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest. 2009;119(6):1420-1428.
Sarli G, Preziosi R, De Tolla L, Brunetti B, Benazzi C. E-cadherin immunoreactivity in canine mammary tumors. J Vet Diagn Invest. 2004;16(6):542-547.
Yoshida K, Yoshida S, Choisunirachon N, et al. The relationship between clinicopathological features and expression of epithelial and mesenchymal markers in spontaneous canine mammary gland tumors. J Vet Med Sci. 2014;76(10):1321-1327.
Vora HH, Patel NA, Rajvik KN, et al. Cytokeratin and vimentin expression in breast cancer. Int J Biol Markers. 2009;24(1):38-46.
Rismanchi S, Yadegar O, Muhammadnejad S, Amanpour S, Taghizadeh-Jahed M, Muhammadnejad A. Expression of vimentin filaments in canine malignant mammary gland tumors: a simulation of clinicopathological features of human breast cancer. Biomed Rep. 2014;2(5):725-728.
Matos AJ, Lopes C, Carvalheira J, Santos M, Rutteman GR, Gartner F. E-cadherin expression in canine malignant mammary tumours: relationship to other clinico-pathological variables. J Comp Pathol. 2006;134(2-3):182-189.
Little MP. Cancer models, genomic instability and somatic cellular Darwinian evolution. Biol Direct. 2010;5:19.
Den Otter W, Koten JW, Van der Vegt BJ, et al. Oncogenesis by mutations in anti-oncogenes: a view. Anticancer Res. 1990;10(2B):475-487.
de Souza TA, de Campos CB, De Biasi Bassani Goncalves A, et al. Relationship between the inflammatory tumor microenvironment and different histologic types of canine mammary tumors. Res Vet Sci. 2018;119:209-214.
Sorenmo KU, Durham AC, Radaelli E, et al. The estrogen effect; clinical and histopathological evidence of dichotomous influences in dogs with spontaneous mammary carcinomas. PLoS One. 2019;14(10):e0224504.
Yue W, Yager JD, Wang JP, Jupe ER, Santen RJ. Estrogen receptor-dependent and independent mechanisms of breast cancer carcinogenesis. Steroids. 2013;78(2):161-170.
Kim J, Bae JS. Tumor-associated macrophages and neutrophils in tumor microenvironment. Mediators Inflamm. 2016;2016:1-11.
Chai H, Brown RE. Field effect in cancer-an update. Ann Clin Lab Sci. 2009;39(4):331-337.
Yan PS, Venkataramu C, Ibrahim A, et al. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res. 2006;12(22):6626-6636.