Structure-Guided Optimization of Dipeptidyl Inhibitors of Norovirus 3CL Protease.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 10 2020
22 10 2020
Historique:
pubmed:
19
9
2020
medline:
19
12
2020
entrez:
18
9
2020
Statut:
ppublish
Résumé
Acute gastroenteritis caused by noroviruses has a major impact on public health worldwide in terms of morbidity, mortality, and economic burden. The disease impacts most severely immunocompromised patients, the elderly, and children. The current lack of approved vaccines and small-molecule therapeutics for the treatment and prophylaxis of norovirus infections underscores the need for the development of norovirus-specific drugs. The studies described herein entail the use of the
Identifiants
pubmed: 32945669
doi: 10.1021/acs.jmedchem.0c01252
doi:
Substances chimiques
Antiviral Agents
0
Dipeptides
0
Protease Inhibitors
0
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
11945-11963Subventions
Organisme : NIAID NIH HHS
ID : R01 AI109039
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM110761
Pays : United States