New indole alkaloids from the seeds of Datura metel L.

Antineoplastic Agents, Phytogenic / isolation & purification Cell Line, Tumor China Datura metel / chemistry Humans Indole Alkaloids / isolation & purification Molecular Structure Phytochemicals / isolation & purification Seeds / chemistry
Cytotoxic Datura metel Indole alkaloids Solanaceae

Journal

Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R

Informations de publication

Date de publication:
Oct 2020
Historique:
received: 05 08 2020
revised: 08 09 2020
accepted: 12 09 2020
pubmed: 19 9 2020
medline: 18 3 2021
entrez: 18 9 2020
Statut: ppublish

Résumé

Four new indole alkaloids, daturametelindoles A-D (1-4) were isolated from the EtOAc soluble partition of the ethanol extract of the Datura metel seeds. The structures of the new compounds were determined based on spectroscopic evidence, including their 1D- and 2D-NMR spectra and mass spectrometry. In particular, compounds 1-4 were all racemes, confirmed by the optical rotations and CD spectra. Unfortunately, the chiral monomers were not obtained due to the amount, but the developments of their chiral separation and chiral resolution were completed. All isolated compounds were evaluated for cytotoxic effects against human gastric adenocarcinoma cells (SGC-7901), human hepatoma (Hepg2), and human breast cancer (MCF-7).

Identifiants

DOI: 10.1016/j.fitote.2020.104726 PMID: 32946946
pubmed: 32946946
pii: S0367-326X(20)30308-7
doi: 10.1016/j.fitote.2020.104726
pii:
doi:

Substances chimiques

Antineoplastic Agents, Phytogenic 0
Indole Alkaloids 0
Phytochemicals 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

104726

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors of this manuscript have declared that no competing interests exist.

Auteurs

Yan Liu (Y)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.

Hai-Bing Jiang (HB)

Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Yuan Liu (Y)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.

Adnan Mohammed Algradi (AM)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.

Anam Naseem (A)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.

Yuan-Yuan Zhou (YY)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.

Xian She (X)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China.
Beijing Key Laboratory of Active Substances Discovery and Drug ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, China.

Bing-You Yang (BY)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China. Electronic address: ybywater@163.com.

Hai-Xue Kuang (HX)

Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin, China. Electronic address: hxkuang@yahoo.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques d'origine végétale › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Régions géographiques › Asie › Extrême-Orient › Chine › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Solanales › Solanaceae › Datura › Datura metel › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indolizine › Indolizidines › Alcaloïdes indoliques › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Facteurs biologiques › Composés phytochimiques › New indole alkaloids from the seeds of Datura metel L.
questionsmedicales.fr › Aliments et boissons › Aliments › Graines › New indole alkaloids from the seeds of Datura metel L.