COVID-19-related and not related Guillain-Barré syndromes share the same management pitfalls during lock down: The experience of Liguria region in Italy.
Aged
COVID-19
/ epidemiology
Case-Control Studies
Comorbidity
Delayed Diagnosis
/ statistics & numerical data
Disease Management
Female
Guillain-Barre Syndrome
/ diagnosis
Humans
Italy
/ epidemiology
Male
Middle Aged
Pandemics
SARS-CoV-2
Social Isolation
Time-to-Treatment
/ statistics & numerical data
AIDP
AMAN
COVID-19
Guillain-Barré syndrome
Miller Fisher
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 11 2020
15 11 2020
Historique:
received:
26
05
2020
revised:
28
08
2020
accepted:
29
08
2020
pubmed:
19
9
2020
medline:
15
12
2020
entrez:
18
9
2020
Statut:
ppublish
Résumé
Recently, during the pandemic infection of the novel SARS-CoV-2, some cases of Guillan-Barré Syndrome (GBS) have been reported. The aim of this work is to report the natural history of patients with GBS, both COVID and not-COVID related, hospitalized in Liguria region, during lock down period, in order to assess clinical features of both groups and possible managements pitfalls due to pandemic emergency. Fifteen GBS patients were admitted to the Hospitals of Liguria, from February 15th to May 3rd 2020, six with SARS-CoV-2 infection and nine without infection. In COVID-19 related GBS five patients presented with classical GBS and one with variant. Two patients presented neurologic symptoms during or shortly after the viral syndrome, suggesting the pattern of a para-infectious profile. Multi-organ involvement, delay in the diagnosis, incomplete work up and start of therapy, were registered in 50% of cases with a GBS-Disability scale ≥4 at follow-up evaluation. In not-COVID-19 related GBS, main problem was diagnostic delay. In three patients the first neurological observation took place after a mean of 33,6 days. Moreover, five patients went to emergency room after an average of 30 days since the onset of neurological symptoms because of fear of contagion. In conclusion, not only SARS-CoV-2 infection can cause GBS, but it can also, due to effects of pandemic on the health organization, affect the outcome of patients with not COVID-19 related GBS.
Identifiants
pubmed: 32947089
pii: S0022-510X(20)30451-2
doi: 10.1016/j.jns.2020.117114
pmc: PMC7462770
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117114Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
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