The influence of choline treatment on behavioral and neurochemical autistic-like phenotype in Mthfr-deficient mice.
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
18 09 2020
18 09 2020
Historique:
received:
09
06
2020
accepted:
07
09
2020
revised:
03
09
2020
pubmed:
20
9
2020
medline:
22
6
2021
entrez:
19
9
2020
Statut:
epublish
Résumé
Imbalanced one carbon metabolism and aberrant autophagy is robustly reported in patients with autism. Polymorphism in the gene methylenetetrahydrofolate reductase (Mthfr), encoding for a key enzyme in this pathway is associated with an increased risk for autistic-spectrum-disorders (ASDs). Autistic-like core and associated behaviors have been described, with contribution of both maternal and offspring Mthfr
Identifiants
pubmed: 32948746
doi: 10.1038/s41398-020-01002-1
pii: 10.1038/s41398-020-01002-1
pmc: PMC7501861
doi:
Substances chimiques
MTHFR protein, mouse
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Choline
N91BDP6H0X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
316Subventions
Organisme : Israel Science Foundation (ISF)
ID : 515/17
Pays : International
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