Vitiligo, From Physiopathology to Emerging Treatments: A Review.
Cytokines
Disease progression
Emerging treatments
JAK
Maintenance therapy
Melanocyte
Regeneration
Resident memory
T cells
Vitiligo
Journal
Dermatology and therapy
ISSN: 2193-8210
Titre abrégé: Dermatol Ther (Heidelb)
Pays: Switzerland
ID NLM: 101590450
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
31
07
2020
pubmed:
20
9
2020
medline:
20
9
2020
entrez:
19
9
2020
Statut:
ppublish
Résumé
Vitiligo is a chronic inflammatory skin disease leading to the loss of epidermal melanocytes. To date, treatment options for vitiligo patients are limited, lack sustained efficacy, and are mainly based on off-label use of immunosuppressive agents, such as systemic or topical steroids or topical calcineurin inhibitors, in association with the use of ultraviolet light. However, recent insights into the understanding of the immune pathogenesis of the disease have led to the identification of several therapeutic targets and the development of targeted therapies that are now being tested in clinical trials. In this review, based on the physiopathology of the disease, we summarize emerging targets that could be developed for the treatment of vitiligo and discuss recent and ongoing developments of drugs for the management of the disease.
Identifiants
pubmed: 32949337
doi: 10.1007/s13555-020-00447-y
pii: 10.1007/s13555-020-00447-y
pmc: PMC7649199
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
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