Oxygen exposure in early life activates NLRP3 inflammasome in mouse brain.
Hyperoxia
Mice
NLRP3 inflammasome
Neuronal damage
Newborn
White matter damage
Journal
Neuroscience letters
ISSN: 1872-7972
Titre abrégé: Neurosci Lett
Pays: Ireland
ID NLM: 7600130
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
received:
29
05
2020
revised:
25
08
2020
accepted:
11
09
2020
pubmed:
20
9
2020
medline:
18
5
2021
entrez:
19
9
2020
Statut:
ppublish
Résumé
Despite widely known detrimental effects on the developing brain, supplemental oxygen is still irreplaceable in the management of newborn infants with respiratory distress. Identifying downstream mechanisms underlying oxygen toxicity is a key step for development of new neuroprotective strategies. Main purpose of this study is to investigate whether NLRP3 inflammasome activation has a role in the pathogenesis of hyperoxia-induced preterm brain injury. C57BL6 pups were randomly divided into either a hyperoxia group (exposed to 90 % oxygen from birth until postnatal day 7) or control group (maintained in room air; 21 % O
Identifiants
pubmed: 32949661
pii: S0304-3940(20)30659-5
doi: 10.1016/j.neulet.2020.135389
pii:
doi:
Substances chimiques
Inflammasomes
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nlrp3 protein, mouse
0
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135389Informations de copyright
Copyright © 2020. Published by Elsevier B.V.