Implications of NADPH oxidase 5 in vascular diseases.

Cardiovascular Diseases / enzymology Diabetes Mellitus / enzymology Endothelium, Vascular / enzymology Humans NADPH Oxidase 5 / metabolism
Endothelial dysfunction Inflammation NADPH oxidase 5 Oxidative stress Vascular diseases

Journal

The international journal of biochemistry & cell biology
ISSN: 1878-5875
Titre abrégé: Int J Biochem Cell Biol
Pays: Netherlands
ID NLM: 9508482

Informations de publication

Date de publication:
11 2020
Historique:
received: 07 07 2020
revised: 07 09 2020
accepted: 14 09 2020
pubmed: 20 9 2020
medline: 20 8 2021
entrez: 19 9 2020
Statut: ppublish

Résumé

Oxidative stress is one of the main mechanisms involved in the pathophysiology of vascular diseases. Among others, oxidative stress promotes endothelial dysfunction, and accelerated ageing and remodelling of vasculature. Lately, NADPH oxidases have been demonstrated to be involved in cardiovascular diseases. NADPH oxidase 5 has emerged as a new player in oxidative stress-mediated endothelial alterations, involved in the pathophysiology of hypertension, diabetes, atherosclerosis, myocardial infarction and stroke. This oxidase seems to mediate its detrimental effects by promoting inflammation. NADPH oxidase 5 has been studied in a lesser extent compared with the other members of the NADPH oxidase family due to its loss in the rodent genome, the main experimental research model. In addition, its potential as a therapeutic target remains unexplored given the lack of specific inhibitors. In this review the latest findings on NADPH oxidase 5 regulation, implications in vascular pathophysiology and therapeutic approaches will be updated.

Identifiants

DOI: 10.1016/j.biocel.2020.105851 PMID: 32949687
pubmed: 32949687
pii: S1357-2725(20)30168-0
doi: 10.1016/j.biocel.2020.105851
pii:
doi:

Substances chimiques

NADPH Oxidase 5 EC 1.6.3.-
NOX5 protein, human EC 1.6.3.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105851

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Javier Marqués (J)

Department of Biochemistry and Genetics, University of Navarra, Pamplona Spain; Navarra Institute for Health Research (IdiSNA), Pamplona Spain.

Adriana Cortés (A)

Department of Biochemistry and Genetics, University of Navarra, Pamplona Spain; Navarra Institute for Health Research (IdiSNA), Pamplona Spain.

Álvaro Pejenaute (Á)

Department of Biochemistry and Genetics, University of Navarra, Pamplona Spain; Navarra Institute for Health Research (IdiSNA), Pamplona Spain.

Guillermo Zalba (G)

Department of Biochemistry and Genetics, University of Navarra, Pamplona Spain; Navarra Institute for Health Research (IdiSNA), Pamplona Spain. Electronic address: gzalba@unav.es.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Implications of NADPH oxidase 5 in vascular diseases.
questionsmedicales.fr › Maladies endocriniennes › Diabète › Implications of NADPH oxidase 5 in vascular diseases.
questionsmedicales.fr › Tissus › Épithélium › Endothélium › Endothélium vasculaire › Implications of NADPH oxidase 5 in vascular diseases.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Implications of NADPH oxidase 5 in vascular diseases.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › NADPH oxidase › NADPH Oxidase 5 › Implications of NADPH oxidase 5 in vascular diseases.