[Diagnostic strategy in pediatrics soft tissue sarcomas].
Stratégie diagnostique des sarcomes des tissus mous de l’enfant et adolescent.
Adolescents
Diagnostic
Diagnostic guidelines
Pediatric cancer
Pédiatrie
Recommandations de prise en charge
Sarcomes des parties molles
Soft part sarcomas
Journal
Bulletin du cancer
ISSN: 1769-6917
Titre abrégé: Bull Cancer
Pays: France
ID NLM: 0072416
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
22
02
2020
revised:
09
06
2020
accepted:
18
06
2020
pubmed:
21
9
2020
medline:
30
10
2020
entrez:
20
9
2020
Statut:
ppublish
Résumé
Soft tissue sarcomas in children are rare tumor, representing around 6 to 7% of children cancer. They spread mostly sporadically (90%) and therefore are rarely associated to an underlying constitutional genetic disease (10%). About half of those sarcomas are rhabdomyosarcomas and the others are a very heterogenous histologic group with various bio-pathologies and prognosis. Clinical presentation is mainly a soft tissue lump often difficult to distinguish from more frequent benign causes (malformative, infectious, benign, or pseudotumor). Inappropriate initial diagnosis work-up has a strong impact on soft tissue sarcomas' prognosis. Adapted complementary investigations (first ultrasound and MRI) are important to compile arguments for a malign origin and to indicate a biopsy. However, predictive value of imaging exams still remains imperfect, and histological analysis by percutaneous image-guided biopsy and sometimes by surgical biopsy is often necessary. Authors realize an update on optimal diagnostic pathway including molecular tests in presence of a soft tissue mass in a child.
Identifiants
pubmed: 32950242
pii: S0007-4551(20)30323-4
doi: 10.1016/j.bulcan.2020.06.008
pii:
doi:
Types de publication
Journal Article
Langues
fre
Sous-ensembles de citation
IM
Pagination
963-971Informations de copyright
Copyright © 2020 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.