Reliability and Validity of Pupillary Response During Dual-Task Balance in Parkinson Disease.
Parkinson disease
Rehabilitation
Reproducibility of results
Journal
Archives of physical medicine and rehabilitation
ISSN: 1532-821X
Titre abrégé: Arch Phys Med Rehabil
Pays: United States
ID NLM: 2985158R
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
14
05
2020
revised:
21
07
2020
accepted:
12
08
2020
pubmed:
21
9
2020
medline:
16
3
2021
entrez:
20
9
2020
Statut:
ppublish
Résumé
To investigate the reliability and validity of pupillary response during dual-task balance conditions in individuals with Parkinson disease (PD). Cross-sectional study. University of Kansas Medical Center Parkinson's Disease and Movement Disorder Center. Participants (N=68) included individuals with PD (n=33) and healthy controls (n=35). Not applicable. Pupillary response was the main outcome measure that was measured during the following conditions: single-task balance eyes open, single-task balance eyes occluded, dual-task eyes open, and dual-task eyes occluded. After each condition, the National Aeronautics and Space Administration-Task Load Index (NASA-TLX) was administered to assess self-reported cognitive workload. To examine the test-retest reliability of the pupillary response, the conditions were administered twice for each individual within 2 hours. Intraclass correlation coefficients (ICC) were used to analyze the test-retest reliability of pupillary response in each condition for both groups. Pearson's r correlation was used to assess the convergent validity of pupillary response against the NASA-TLX. The test-retest reliability was excellent for both groups in almost all conditions (ICC>0.75). There were no correlations between pupillary response and the NASA-TLX. However, increased mental demand (a subitem of the NASA-TLX) significantly correlated with increased pupillary response in individuals with PD (r=0.38; P=.03). Pupillary response showed excellent test-retest reliability and validity during dual-task balance for individuals with PD and healthy controls. Overall, these results suggest that pupillary response represents a stable index of cognitive workload during dual-task balance in individuals with PD.
Identifiants
pubmed: 32950465
pii: S0003-9993(20)30564-5
doi: 10.1016/j.apmr.2020.08.008
pmc: PMC7914127
mid: NIHMS1630099
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
448-455Subventions
Organisme : NIA NIH HHS
ID : K01 AG058785
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD057850
Pays : United States
Informations de copyright
Copyright © 2020 American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
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