Persistence of oral pre-exposure prophylaxis (PrEP) among adolescent girls and young women initiating PrEP for HIV prevention in Kenya.


Journal

AIDS care
ISSN: 1360-0451
Titre abrégé: AIDS Care
Pays: England
ID NLM: 8915313

Informations de publication

Date de publication:
06 2021
Historique:
pubmed: 22 9 2020
medline: 25 5 2021
entrez: 21 9 2020
Statut: ppublish

Résumé

The Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe (DREAMS) Initiative aims to reduce HIV infections among adolescent girls and young women (AGYW) in Africa. Oral pre-exposure prophylaxis (PrEP) is offered through DREAMS in Kenya to eligible AGYW in high burden counties including Kisumu and Homa Bay. This study examines PrEP persistence among AGYW in high burden community-based PrEP delivery settings. We evaluated PrEP persistence among AGYW in the DREAMS PrEP program in Kisumu and Homa Bay using survival analysis and programmatic PrEP refill data collected between March through December 2017. Among 1,259 AGYW who initiated PrEP during the study period, the median persistence time in the program was 56 days (95% CI: 49-58 days) and the proportion who persisted 3 months later was 37% (95% CI: 34-40%). Persistence varied by county (

Identifiants

pubmed: 32951437
doi: 10.1080/09540121.2020.1822505
pmc: PMC7981281
mid: NIHMS1628162
doi:

Substances chimiques

Anti-HIV Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

712-720

Subventions

Organisme : NICHD NIH HHS
ID : R01 HD094682
Pays : United States

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Auteurs

Jean de Dieu Tapsoba (J)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Sahar Z Zangeneh (SZ)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Eline Appelmans (E)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Siavash Pasalar (S)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Kira Mori (K)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Lily Peng (L)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Janice Tao (J)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Paul Drain (P)

Department of Global Health, University of Washington, Seattle, WA, USA.

Gordon Okomo (G)

Ministry of Health, Nairobi, Kenya.

Stanley Bii (S)

United States Agency for International Development, Nairobi, Kenya.

James Mukabi (J)

PATH, Nairobi, Kenya.

Stephanie Zobrist (S)

PATH, Seattle, WA, USA.

Martha Brady (M)

PATH, Seattle, WA, USA.

Rael Obanda (R)

PATH, Kisumu, Kenya.

Daniel Oluoch Madiang (DO)

PATH, Kisumu, Kenya.

Jane Cover (J)

PATH, Seattle, WA, USA.

Ann Duerr (A)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Ying Qing Chen (YQ)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Christopher Obong'o (C)

PATH, Kisumu, Kenya.

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Classifications MeSH