Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
Hippocampus
Inapparent infection
Langat virus
Learning and memory
Tick-borne encephalitis virus
Type I interferon
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
20 Sep 2020
20 Sep 2020
Historique:
received:
19
03
2020
accepted:
10
09
2020
entrez:
21
9
2020
pubmed:
22
9
2020
medline:
22
7
2021
Statut:
epublish
Résumé
Tick-borne encephalitis virus (TBEV) is an important human pathogen that can cause the serious illness tick-borne encephalitis (TBE). Patients with clinical symptoms can suffer from severe meningoencephalitis with sequelae that include cognitive disorders and paralysis. While less than 30% of patients with clinical symptoms develop meningoencephalitis, the number of seropositive individuals in some regions indicates a much higher prevalence of TBEV infections, either with no or subclinical symptoms. The functional relevance of these subclinical TBEV infections and their influence on brain functions, such as learning and memory, has not been investigated so far. To compare the effect of low and high viral replication in the brain, wildtype and Irf-7 In contrast to susceptible Irf-7 In this study, we demonstrate that subclinical infections by viruses from the TBEV-serogroup affected anxiety-like behavior. Virus replication in the olfactory bulb induced far-reaching effects on hippocampal neuron morphology and impaired hippocampus-dependent learning and memory formation.
Sections du résumé
BACKGROUND
BACKGROUND
Tick-borne encephalitis virus (TBEV) is an important human pathogen that can cause the serious illness tick-borne encephalitis (TBE). Patients with clinical symptoms can suffer from severe meningoencephalitis with sequelae that include cognitive disorders and paralysis. While less than 30% of patients with clinical symptoms develop meningoencephalitis, the number of seropositive individuals in some regions indicates a much higher prevalence of TBEV infections, either with no or subclinical symptoms. The functional relevance of these subclinical TBEV infections and their influence on brain functions, such as learning and memory, has not been investigated so far.
METHODS
METHODS
To compare the effect of low and high viral replication in the brain, wildtype and Irf-7
RESULTS
RESULTS
In contrast to susceptible Irf-7
CONCLUSION
CONCLUSIONS
In this study, we demonstrate that subclinical infections by viruses from the TBEV-serogroup affected anxiety-like behavior. Virus replication in the olfactory bulb induced far-reaching effects on hippocampal neuron morphology and impaired hippocampus-dependent learning and memory formation.
Identifiants
pubmed: 32951602
doi: 10.1186/s12974-020-01951-w
pii: 10.1186/s12974-020-01951-w
pmc: PMC7504599
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
278Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SFB854/AK
Organisme : Bundesministerium für Bildung und Forschung
ID : 01KI1728H
Organisme : Helmholtz Zentrum für Infektionsfoschung (DE)
ID : HIRSIB
Organisme : Federal state of Saxony-Anhalt and the European Structural and Investmant Funds
ID : ESF ZS/2016/08/80645
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