Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis.

Amino Acid Sequence Amyloid / chemistry Chromatography, High Pressure Liquid Electrophoresis, Gel, Two-Dimensional Humans Immunoglobulin Light Chains / chemistry Immunoglobulin Light-chain Amyloidosis / metabolism Myocardium / metabolism Peptides / analysis Protein Structure, Secondary Protein Structure, Tertiary Proteolysis Tandem Mass Spectrometry
amyloid amyloid fibrils cardiomyopathy fibril mass spectrometry (MS) protein aggregation protein conformation protein structure proteolysis proteomics structural biology

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
04 12 2020
Historique:
received: 15 03 2020
revised: 04 09 2020
pubmed: 22 9 2020
medline: 5 5 2021
entrez: 21 9 2020
Statut: ppublish

Résumé

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins.

Identifiants

DOI: 10.1074/jbc.RA120.013461 PMID: 32952127 PMC: PMC7864057
pubmed: 32952127
pii: S0021-9258(17)50476-7
doi: 10.1074/jbc.RA120.013461
pmc: PMC7864057
pii:
doi:

Substances chimiques

Amyloid 0
Immunoglobulin Light Chains 0
Peptides 0

Banques de données

PDB
['6MG4', '5MUH']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16572-16584

Informations de copyright

© 2020 Lavatelli et al.

Déclaration de conflit d'intérêts

Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.

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Auteurs

Francesca Lavatelli (F)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy. Electronic address: francesca.lavatelli@unipv.it.

Giulia Mazzini (G)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Stefano Ricagno (S)

Department of Biosciences, Università degli Studi di Milano, Milan, Italy.

Federica Iavarone (F)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Faculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy; Clinical Chemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.

Paola Rognoni (P)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Paolo Milani (P)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Mario Nuvolone (M)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Paolo Swuec (P)

Department of Biosciences, Università degli Studi di Milano, Milan, Italy; Cryo-Electron Microscopy Facility, Human Technopole, Milan, Italy.

Serena Caminito (S)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Masayoshi Tasaki (M)

Department of Morphological and Physiological Sciences, Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan; Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Antonio Chaves-Sanjuan (A)

Department of Biosciences, Università degli Studi di Milano, Milan, Italy.

Andrea Urbani (A)

Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Faculty of Medicine, Università Cattolica del Sacro Cuore, Rome, Italy; Clinical Chemistry, Biochemistry and Molecular Biology Clinic, Fondazione Policlinico Agostino Gemelli IRCCS, Rome, Italy.

Giampaolo Merlini (G)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

Giovanni Palladini (G)

Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Mass spectrometry characterization of light...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Amyloïde › Mass spectrometry characterization of light...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Mass spectrometry characterization of light...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Électrophorèse › Électrophorèse bidimensionnelle sur gel › Mass spectrometry characterization of light...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mass spectrometry characterization of light...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Sous-unités des immunoglobulines › Chaines légères des immunoglobulines › Mass spectrometry characterization of light...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Paraprotéinémies › Amylose à chaine légère d'immunoglobuline › Mass spectrometry characterization of light...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Mass spectrometry characterization of light...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Mass spectrometry characterization of light...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Mass spectrometry characterization of light...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Mass spectrometry characterization of light...
questionsmedicales.fr › Métabolisme › Protéolyse › Mass spectrometry characterization of light...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Mass spectrometry characterization of light...