Germline ancestry influences the evolutionary disease course in lung adenocarcinomas.
cancer
genomics
germline ancestry
somatic evolution
Journal
Evolutionary applications
ISSN: 1752-4571
Titre abrégé: Evol Appl
Pays: England
ID NLM: 101461828
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
27
11
2019
revised:
15
02
2020
accepted:
05
03
2020
entrez:
21
9
2020
pubmed:
22
9
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Precision medicine relies on targeting specific somatic alterations present in a patient's tumor. However, the extent to which germline ancestry may influence the somatic burden of disease has received little attention. We estimated the genetic ancestry of non-small-cell lung cancer (NSCLC) patients and performed an in-depth analysis of the influence of genetic ancestry on the evolutionary disease course. Compared with European Americans (EA), African Americans (AA) with lung adenocarcinoma (LUAD) were found to be significantly younger and smoke significantly less. However, LUADs from AAs exhibited a significantly higher somatic mutation burden, with a more pronounced tobacco carcinogen footprint and increased frequencies of alterations affecting cancer genes. Conversely, no significant differences were observed between lung squamous cell carcinomas (LUSC) from EAs and AAs. Our results suggest germline ancestry influences the somatic evolution of LUAD but not LUSC.
Identifiants
pubmed: 32952607
doi: 10.1111/eva.12964
pii: EVA12964
pmc: PMC7484830
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1550-1557Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
None declared.
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