Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells.

Breast neoplasm Neoplasm Phenolic compounds Stem cells Therapy resistance

Journal

Iranian journal of basic medical sciences
ISSN: 2008-3866
Titre abrégé: Iran J Basic Med Sci
Pays: Iran
ID NLM: 101517966

Informations de publication

Date de publication:
Aug 2020
Historique:
entrez: 21 9 2020
pubmed: 22 9 2020
medline: 22 9 2020
Statut: ppublish

Résumé

Cancer stem cells (CSCs) are known as the major reason for therapy resistance. Recently, natural herbal compounds are suggested to have a significant role in inhibiting the breast cancer stem cells (BCSCs). The aim of this study was to explore the effective natural herbal compounds against BCSCs.This review article was designed based on the BCSCs, mechanisms of therapy resistance and natural herbal compounds effective to inhibit their activity. Therefore, Science direct, PubMed and Scopus databases were explored and related original articles were investigated from 2010 to 2019. BCSCs use different mechanisms including special membrane transporters, anti-apoptotic, pro-survival, and self-renewal- related signaling pathways. Natural herbal compounds could disturb these mechanisms, therefore may inhibit or eradicate the BCSCs. Studies show that a broad range of plants, either as a food or medicine, contain anti-cancer agents that phenolic components and their different derivatives share a large quantity. Natural herbal compounds play a pivotal role in the eradication of BCSCs, through the inhibition of biological activities and induction of apoptosis. Although it is necessary to conduct more clinical investigation.

Identifiants

pubmed: 32952942
doi: 10.22038/ijbms.2020.43745.10270
pmc: PMC7478260
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

970-983

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Auteurs

Azam Bozorgi (A)

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Saber Khazaei (S)

Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Abbasali Khademi (A)

Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

Mozafar Khazaei (M)

Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Classifications MeSH