Rates of positive lung cancer screening examinations in academic versus community practice.

The benefits and harms of lung cancer screening reported in the National Lung Screening Trial (NLST) likely differ from those observed in academic and community settings. High rates of positive screening findings in the NLST led to the development of the Lung CT Screening Reporting and Data System (Lung-RADS) to standardize interpretation and reporting. We conducted a prospective observational study of lung cancer screening data from four lung cancer screening sites in North Carolina to compare prospective use of Lung-RADS in a real-world screened population versus Lung-RADS retrospectively applied to the NLST, and to determine if Lung-RADS assessment use differs in academic versus community settings. We included 4,037 screening examinations from 11/2014 to 12/2018 in academic and community sites and 75,126 NLST LDCT screening exams. On baseline screening exams, the proportion of positive LDCT exams was higher in community versus academic sites or the NLST (17.7%

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2020 Translational Lung Cancer Research. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tlcr-19-673). LMH, TB and RHV report grants from NIH/NCI during the conduct of the study. MPR reports grants from NIH/NCI during the conduct of the study; Consultant for a Research Workshop held by Johnson & Johnson; Chair, Medical and Scientific Advisory Board for bioAffinity Technologies; and Member, Medical and Scientific Advisory Board for Biodesix. LB has no conflicts of interest to declare.