CAR-T Cells Targeting Epstein-Barr Virus gp350 Validated in a Humanized Mouse Model of EBV Infection and Lymphoproliferative Disease.
CAR-T cells
EBV
PTLD
adoptive T cell therapy
gp350
humanized mice
lymphoma
lymphoproliferation
lytic infection
transplantation
Journal
Molecular therapy oncolytics
ISSN: 2372-7705
Titre abrégé: Mol Ther Oncolytics
Pays: United States
ID NLM: 101666776
Informations de publication
Date de publication:
25 Sep 2020
25 Sep 2020
Historique:
received:
21
05
2020
accepted:
06
08
2020
entrez:
21
9
2020
pubmed:
22
9
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Epstein-Barr virus (EBV) is a latent and oncogenic human herpesvirus. Lytic viral protein expression plays an important role in EBV-associated malignancies. The EBV envelope glycoprotein 350 (gp350) is expressed abundantly during EBV lytic reactivation and sporadically on the surface of latently infected cells. Here we tested T cells expressing gp350-specific chimeric antigen receptors (CARs) containing scFvs derived from two novel gp350-binding, highly neutralizing monoclonal antibodies. The scFvs were fused to CD28/CD3ζ signaling domains in a retroviral vector. The produced gp350CAR-T cells specifically recognized and killed gp350
Identifiants
pubmed: 32953984
doi: 10.1016/j.omto.2020.08.005
pii: S2372-7705(20)30122-4
pmc: PMC7479496
doi:
Types de publication
Journal Article
Langues
eng
Pagination
504-524Informations de copyright
© 2020 The Author(s).
Références
N Engl J Med. 2014 Oct 16;371(16):1507-17
pubmed: 25317870
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8245-50
pubmed: 9653172
Cell Rep. 2013 Oct 31;5(2):458-70
pubmed: 24120866
Mol Ther. 2017 Mar 1;25(3):580-592
pubmed: 28187946
PLoS Pathog. 2020 Jul 15;16(7):e1008560
pubmed: 32667948
Transl Res. 2017 Sep;187:83-92
pubmed: 28755872
Blood. 2012 Mar 15;119(11):2644-56
pubmed: 22138512
J Med Virol. 2002 Mar;66(3):351-9
pubmed: 11793387
Front Oncol. 2019 Feb 25;9:104
pubmed: 30859093
Viruses. 2012 Dec;4(12):3420-39
pubmed: 23342366
Sci Rep. 2015 Jul 23;5:12168
pubmed: 26202875
Blood. 2013 Jun 27;121(26):5113-23
pubmed: 23610374
Am J Pathol. 2019 Mar;189(3):521-539
pubmed: 30593822
Blood. 2016 Jun 30;127(26):3331-40
pubmed: 27207801
Blood. 2010 Feb 4;115(5):925-35
pubmed: 19880495
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16046-16055
pubmed: 31341086
Front Immunol. 2017 Dec 08;8:1709
pubmed: 29276513
Orphanet J Rare Dis. 2006 Jun 26;1:23
pubmed: 16800883
J Exp Med. 2006 Apr 17;203(4):995-1006
pubmed: 16549597
PLoS One. 2013 Dec 17;8(12):e82742
pubmed: 24358223
Clin Exp Immunol. 2011 Nov;166(2):269-80
pubmed: 21985373
Proc Natl Acad Sci U S A. 1980 May;77(5):2979-83
pubmed: 6248876
Chin J Cancer. 2014 Dec;33(12):591-7
pubmed: 25418190
Front Immunol. 2018 Nov 22;9:2734
pubmed: 30524448
Nat Rev Microbiol. 2019 Nov;17(11):691-700
pubmed: 31477887
J Virol. 2011 Jan;85(1):165-77
pubmed: 20980506
Mol Ther. 2020 May 6;28(5):1251-1262
pubmed: 32145203
Bone Marrow Transplant. 2016 Apr;51(4):596-7
pubmed: 26595075
Bone Marrow Transplant. 2020 Jan;55(1):25-39
pubmed: 31089285
Am J Pathol. 2017 Jun;187(6):1380-1398
pubmed: 28432872
EMBO Mol Med. 2020 Jul 7;12(7):e8662
pubmed: 32578942
Oncotarget. 2017 Jul 4;8(27):44266-44280
pubmed: 28574826
J Immunol. 2014 May 15;192(10):4636-47
pubmed: 24740501
Science. 2018 Mar 23;359(6382):1361-1365
pubmed: 29567707
Front Immunol. 2018 Dec 12;9:2945
pubmed: 30619305
Blood. 2009 Nov 5;114(19):4002-8
pubmed: 19724053
Br J Haematol. 2018 Aug;182(3):330-343
pubmed: 29741774
Blood. 1998 Feb 15;91(4):1373-81
pubmed: 9454768
J Biomed Res. 2014 Nov;28(6):468-75
pubmed: 25469116
J Clin Oncol. 2015 Feb 20;33(6):540-9
pubmed: 25154820
PLoS Pathog. 2018 Mar 12;14(3):e1006891
pubmed: 29529058
Trends Pharmacol Sci. 2016 Mar;37(3):220-230
pubmed: 26705086
Sci Rep. 2017 Sep 7;7(1):10813
pubmed: 28883511
Blood. 2015 Aug 20;126(8):983-92
pubmed: 26056165
Hematol Oncol. 2018 Feb;36(1):98-103
pubmed: 28707331
Oncotarget. 2014 Dec 15;5(23):12189-202
pubmed: 25361008
Oncotarget. 2017 Feb 7;8(6):10238-10254
pubmed: 28052012
Nat Commun. 2018 Nov 7;9(1):4663
pubmed: 30405107
Hemasphere. 2019 Feb 01;3(1):e172
pubmed: 31723811
Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15036-41
pubmed: 12409611
Front Pharmacol. 2014 Oct 28;5:235
pubmed: 25389405
Gut. 2016 Mar;65(3):512-23
pubmed: 25661083
PLoS One. 2019 Dec 17;14(12):e0226436
pubmed: 31846480
J Transl Med. 2018 Feb 08;16(1):26
pubmed: 29422056
J Gen Virol. 1995 Jun;76 ( Pt 6):1401-8
pubmed: 7782768
Blood. 2007 Aug 15;110(4):1123-31
pubmed: 17468341
Hum Gene Ther. 2020 Apr;31(7-8):423-439
pubmed: 32159399
J Infect Dis. 2006 Sep 1;194(5):584-7
pubmed: 16897655
Semin Immunopathol. 2020 Apr;42(2):131-142
pubmed: 32232535
Mol Ther Methods Clin Dev. 2015 Jan 07;1:14060
pubmed: 26052526
JCI Insight. 2018 Jan 11;3(1):
pubmed: 29321369