Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods.
cancer biophysics
cancer invasion
cell mechanics
collective cell dynamics
epithelial–mesenchymal transition
unjamming
Journal
ACS biomaterials science & engineering
ISSN: 2373-9878
Titre abrégé: ACS Biomater Sci Eng
Pays: United States
ID NLM: 101654670
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
21
9
2020
pubmed:
1
1
2019
medline:
1
1
2019
Statut:
ppublish
Résumé
Cell migration is essential for regulating many biological processes in physiological or pathological conditions, including embryonic development and cancer invasion. In vitro and in silico studies suggest that collective cell migration is associated with some biomechanical particularities such as restructuring of extracellular matrix (ECM), stress and force distribution profiles, and reorganization of the cytoskeleton. Therefore, the phenomenon could be understood by an in-depth study of cells' behavior determinants, including but not limited to mechanical cues from the environment and from fellow "travelers". This review article aims to cover the recent development of experimental and computational methods for studying the biomechanics of collective cell migration during cancer progression and invasion. We also summarized the tested hypotheses regarding the mechanism underlying collective cell migration enabled by these methods. Together, the paper enables a broad overview on the methods and tools currently available to unravel the biophysical mechanisms pertinent to cell collective migration as well as providing perspectives on future development toward eventually deciphering the key mechanisms behind the most lethal feature of cancer.
Identifiants
pubmed: 32953985
doi: 10.1021/acsbiomaterials.8b01428
pmc: PMC7500334
mid: NIHMS1038353
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3766-3787Subventions
Organisme : NCI NIH HHS
ID : U01 CA202123
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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