Differential effects of deep brain stimulation and levodopa on brain activity in Parkinson's disease.
Parkinson’s disease
deep brain stimulation
dopaminergic treatment
functional magnetic resonance imaging
levodopa
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
07
2019
revised:
21
10
2019
accepted:
09
12
2019
entrez:
21
9
2020
pubmed:
22
9
2020
medline:
22
9
2020
Statut:
epublish
Résumé
Levodopa is the first-line treatment for Parkinson's disease, although the precise mechanisms mediating its efficacy remain elusive. We aimed to elucidate treatment effects of levodopa on brain activity during the execution of fine movements and to compare them with deep brain stimulation of the subthalamic nuclei. We studied 32 patients with Parkinson's disease using functional MRI during the execution of finger-tapping task, alternating epochs of movement and rest. The task was performed after withdrawal and administration of a single levodopa dose. A subgroup of patients (
Identifiants
pubmed: 32954278
doi: 10.1093/braincomms/fcaa005
pii: fcaa005
pmc: PMC7425344
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcaa005Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
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